Survey of the Clinical, Cytological, and Histopathological Features Associated with Neoplasms in Captive Avian Species in Melbourne, Australia.

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES
Michelle Sutherland, Kathy Luk, Natalie Courtman, Richard Ploeg
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引用次数: 0

Abstract

Over a 3.5-year period, tissue samples from 141 companion and aviary birds with clinically suspected, naturally occurring solid neoplasms were collected via surgical biopsy (n = 53) or at necropsy examination (n = 88) from a population of birds presenting to an avian veterinary clinic in Melbourne, Australia. Neoplastic processes were identified in 73.7% (n = 104) of samples, with 83.7% (n = 87) being interpreted as malignant neoplasia and 16.3% (n = 17) being interpreted as benign neoplasia. The overall estimated prevalence of neoplasia in the study population (n = 5125) was 2.45% (95% confidence interval, 2-2.97%). The gastrointestinal and reproductive tracts were the most commonly affected systems. The most common presenting signs were nonspecific and included lethargy, coelomic distension, and inappetence. In 59 cases, fine-needle aspirates (FNAs) and impression smears were also obtained and evaluated cytologically. The accuracy of cytology for detecting neoplasia in birds and for determining whether a neoplastic process was benign or malignant was assessed by using histopathology as the "gold standard." There was complete agreement between the cytological and histopathological diagnoses in 72.8% (43/59) of cases. Cytology correctly identified 87.5% of these cases (35/40) as malignant neoplasms and 55.6% (5/9) as benign processes. There was no significant difference between the use of cytology and histopathology for the detection of malignant neoplasia in birds (P = 0.185). The accuracies of FNAs and impression smears for examining avian tumors were also compared. Overall, the best cell preservation was obtained by performing impression smears from tissues, with 62.2% (n = 28) returning high cellularity for cytological examination, compared to 53.8% (n = 14) when samples were obtained by FNA. This study provides an overview of the types and prevalence of neoplasms in a captive bird population from Australia, correlates physical examination findings with tumor types, and provides evidence that cytology is a reliable preliminary diagnostic tool for detecting neoplasia in birds.

澳大利亚墨尔本圈养鸟类中与肿瘤相关的临床、细胞学和组织病理学特征调查。
在3.5年的时间里,通过手术活检(n = 53)或尸检检查(n = 88)从澳大利亚墨尔本一家鸟类兽医诊所就诊的鸟类群体中收集了141只临床怀疑自然发生实体瘤的伴侣和鸟的组织样本。73.7% (n = 104)的样本中发现了肿瘤过程,其中83.7% (n = 87)被解释为恶性肿瘤,16.3% (n = 17)被解释为良性肿瘤。研究人群(n = 5125)中瘤变的总体估计患病率为2.45%(95%可信区间为2-2.97%)。胃肠道和生殖道是最常见的感染系统。最常见的症状是非特异性的,包括嗜睡、体腔扩张和食欲不振。在59例中,还获得了细针抽吸(FNAs)和印迹涂片并进行了细胞学评估。用组织病理学作为“金标准”来评估细胞学检测鸟类肿瘤和确定肿瘤过程是良性还是恶性的准确性。72.8%(43/59)病例的细胞学诊断与组织病理学诊断完全吻合。细胞学检查正确诊断87.5%(35/40)为恶性肿瘤,55.6%(5/9)为良性肿瘤。细胞学和组织病理学对鸟类恶性肿瘤的检测差异无统计学意义(P = 0.185)。比较了FNAs和印迹涂片检测禽类肿瘤的准确性。总体而言,通过组织印迹涂片获得最佳的细胞保存,62.2% (n = 28)的细胞在细胞学检查中返回高细胞度,而FNA获得的样本为53.8% (n = 14)。本研究概述了澳大利亚圈养鸟类中肿瘤的类型和患病率,将体格检查结果与肿瘤类型联系起来,并提供了细胞学是检测鸟类肿瘤的可靠初步诊断工具的证据。
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来源期刊
Journal of Avian Medicine and Surgery
Journal of Avian Medicine and Surgery 农林科学-兽医学
CiteScore
0.90
自引率
0.00%
发文量
52
审稿时长
>36 weeks
期刊介绍: The Journal of Avian Medicine and Surgery is an international journal of the medicine and surgery of both captive and wild birds. Published materials include scientific articles, case reports, editorials, abstracts, new research, and book reviews.
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