Effects of Atorvastatin and Rosuvastatin on Blood Lipids in Quaker Parrots (Myiopsitta monachus).

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES
Hugues Beaufrère, Trinita Barboza, Alysha Burnett, Ken D Stark, R Darren Wood
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引用次数: 1

Abstract

Statin drugs are the most effective class of hypolipidemic and antiatherosclerotic drugs, with atorvastatin and rosuvastatin being the most effective. While the use of statins would be a tremendous asset in the treatment of dyslipidemia and lipid-accumulation disorders in birds, there are only limited data available regarding their use and effectiveness in psittacine species. Two consecutive randomized crossover trials on Quaker parrots (Myiopsitta monachus) were performed to study the effect of atorvastatin and rosuvastatin. Ten birds were used in an initial balanced crossover experiment with 5 oral treatments (control; atorvastatin 10 mg/kg q12h and q24h; rosuvastatin 10 mg/kg q12h and q24h) for 2 weeks each. Plasma lipidomics and lipoprotein profiling were performed after each treatment. Twelve birds were used in a second experiment consisting of 2 parallel crossover studies, each with 6 birds either fed their regular diet or a 0.3% cholesterol diet. In the 2 parallel crossover studies, the treatment group was administered atorvastatin 20 mg/kg orally q12h and the control group a placebo suspension orally q12h. Plasma lipidomics, lipoprotein profiles, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity were subsequently measured. Results were analyzed with serial linear mixed models and trends were assessed graphically. No statistically significant effect of any statin treatment was detected on plasma lipids, lipoproteins, creatinine kinase, or HMG-CoA reductase activity. In the first trial, all the rosuvastatin treatments led to some nonsignificant decreases in several triacylglycerol species, while in the second trial this was only observed in the birds on atorvastatin 20 mg/kg q12h being fed their regular diet. Quaker parrots may require much higher doses of statin drugs to show significant and clinically useful lipid-lowering effects.

阿托伐他汀和瑞舒伐他汀对桂格鹦鹉血脂的影响。
他汀类药物是最有效的一类降血脂和抗动脉粥样硬化药物,其中阿托伐他汀和瑞舒伐他汀是最有效的。虽然他汀类药物的使用将是治疗鸟类血脂异常和脂质积累障碍的巨大资产,但关于其在鹦鹉种群中的使用和有效性的数据有限。为了研究阿托伐他汀和瑞舒伐他汀对贵格鹦鹉(Myiopsitta monachus)的影响,我们进行了两个连续的随机交叉试验。10只禽鸟进行初始平衡交叉试验,采用5种口服治疗(对照;阿托伐他汀10mg /kg q12h和q24h;瑞舒伐他汀10 mg/kg (q12h和q24h),每组2周。每次治疗后进行血浆脂质组学和脂蛋白谱分析。第二次实验采用了12只鸟,包括2个平行交叉研究,每组6只鸟喂食常规饮食或0.3%胆固醇饮食。在两项平行交叉研究中,治疗组给予阿托伐他汀20 mg/kg口服,q12h;对照组给予安慰剂混悬液口服,q12h。随后测定血浆脂质组学、脂蛋白谱和3-羟基-3-甲基戊二酰辅酶A (HMG-CoA)还原酶活性。结果用序列线性混合模型进行分析,并以图形方式评估趋势。没有发现任何他汀类药物治疗对血脂、脂蛋白、肌酐激酶或HMG-CoA还原酶活性有统计学意义的影响。在第一个试验中,所有的瑞舒伐他汀治疗导致几种三酰甘油种类的一些不显著的减少,而在第二个试验中,只在喂食常规饮食的阿托伐他汀20mg /kg q12h的鸟类中观察到这种情况。贵格鹦鹉可能需要更高剂量的他汀类药物,以显示显着和临床有用的降脂效果。
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来源期刊
Journal of Avian Medicine and Surgery
Journal of Avian Medicine and Surgery 农林科学-兽医学
CiteScore
0.90
自引率
0.00%
发文量
52
审稿时长
>36 weeks
期刊介绍: The Journal of Avian Medicine and Surgery is an international journal of the medicine and surgery of both captive and wild birds. Published materials include scientific articles, case reports, editorials, abstracts, new research, and book reviews.
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