DKI can distinguish high-grade gliomas from IDH1-mutant low-grade gliomas and correlate with their different nuclear-to-cytoplasm ratio: a localized biopsy-based study.

IF 4.7 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
European Radiology Pub Date : 2024-11-01 Epub Date: 2023-11-14 DOI:10.1007/s00330-023-10325-8
Haopeng Pang, Xuefei Dang, Yan Ren, Zhenwei Yao, Yehua Shen, Xiaoyuan Feng, Zhongmin Wang
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引用次数: 0

Abstract

Objectives: To explore whether differences in diffusional kurtosis imaging (DKI) between therapy-naïve high-grade gliomas (HGGs) and low-grade gliomas (LGGs) are related to the cellularity and/or the nuclear-to-cytoplasmic (N/C) ratio.

Methods: We analyzed 44 and 40 diffuse glioma samples that were pathologically confirmed as HGGs and IDH1-mutant LGGs, respectively. The DKI parameters included kurtosis metrics (mean kurtosis [MK], axial kurtosis [K//], and radial kurtosis [K]), and the diffusional metrics (fractional anisotropy [FA], mean diffusion [MD], axial diffusion [λ//], and radial diffusion [λ]). The cellularity and the N/C ratio were compared within LGGs and HGGs using the Mann-Whitney U test (significant level, p < 0.007 [0.05/7]); Bonferroni correction). Spearman's correlation analysis was used to calculate the correlation coefficients among DKI metrics, cellularity, and the N/C ratio at a significant level of p = 0.05.

Results: Excluding FA, all DKI metrics showed significant differences between HGGs and LGGs (all p ≤ 0.001). The N/C ratio of HGGs was significantly higher than that of LGGs; however, differences in cellularity were not significant between the two glioma groups (p = 0.525). Similarly, excluding FA, all DKI metrics were significantly correlated with the N/C ratio in LGGs, with correlation coefficients of - 0.365 (MD), - 0.313 (λ//), - 0.376 (λ), 0.859 (MK), 0.772 (K//), and 0.842 (K//). There was a non-significant correlation between any DKI parameters and the cellularity in LGGs. Additionally, the cellularity and N/C ratios in HGGs did not correlate with any DKI metrics.

Conclusions: DKI differentiate LGGs from HGGs associated with their different N/C ratios.

Clinical relevance statement: This study shows that DKI differentiates LGGs from HGGs may correlated with their different N/C ratios, this could provide a possible histopathological mechanism about why DKI can DKI differentiate LGGs from HGGs.

Key points: • Excluding FA, all DKI metrics showed a significant difference between high-grade gliomas and IDH1-mutant low-grade gliomas. • The nuclear-to-cytoplasm ratios in high-grade gliomas were significantly more extensive than that in IDH1-mutant low-grade gliomas, but not the cellularity. • Significant associations were seen between DKI measures and the N/C ratio; a non-significant correlation was noted between any DKI metric and cellularity in glioma specimens.

Abstract Image

DKI可以区分高级别胶质瘤和idh1突变的低级别胶质瘤,并与它们不同的核质比相关:一项局部活检研究。
目的:探讨therapy-naïve高级别胶质瘤(HGGs)和低级别胶质瘤(LGGs)的弥散峰度成像(DKI)差异是否与细胞结构和/或核质比(N/C)有关。方法:我们分别分析了病理证实为HGGs和idh1突变LGGs的弥漫性胶质瘤样本44例和40例。DKI参数包括峰度指标(平均峰度[MK]、轴向峰度[K//]和径向峰度[K⊥]),以及扩散指标(分数各向异性[FA]、平均扩散[MD]、轴向扩散[λ//]和径向扩散[λ⊥])。使用Mann-Whitney U检验比较LGGs和HGGs的细胞密度和N/C比(显著水平,p)。结果:除FA外,所有DKI指标在HGGs和LGGs之间显示显著差异(p均≤0.001)。hgg的N/C比显著高于lgg;然而,两组胶质瘤的细胞结构差异无统计学意义(p = 0.525)。同样,除FA外,所有DKI指标与lgg的N/C比均显著相关,相关系数为- 0.365 (MD), - 0.313 (λ//), - 0.376 (λ//), 0.859 (MK), 0.772 (K//)和0.842 (K//)。任何DKI参数与LGGs的细胞结构均无显著相关性。此外,hgg的细胞结构和氮碳比与任何DKI指标无关。结论:DKI区分lgg和hgg与不同的N/C比值有关。临床相关性声明:本研究表明DKI区分LGGs与HGGs可能与其N/C比值不同有关,这可能为DKI区分LGGs与HGGs提供了一种可能的组织病理学机制。•除FA外,所有DKI指标均显示高级别胶质瘤和idh1突变低级别胶质瘤之间存在显著差异。•高级别胶质瘤的核质比明显比idh1突变的低级别胶质瘤更广泛,但细胞结构没有变化。•DKI测量与N/C比率之间存在显著关联;在胶质瘤标本中,任何DKI指标与细胞结构之间没有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Radiology
European Radiology 医学-核医学
CiteScore
11.60
自引率
8.50%
发文量
874
审稿时长
2-4 weeks
期刊介绍: European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.
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