Supra- and sub-gingival instrumentation of periodontitis with the adjunctive treatment of a chloramine - a one-year randomized clinical trial study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-22 DOI:10.1080/00016357.2023.2281486

Viveca Wallin-Bengtsson, Ulrica Scherdin-Almhöjd, Ann-Marie Roos-Jansåker

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引用次数: 0

Abstract

Periodontitis is a bacterial-induced disease and for this reason controlling the microbiota is a necessity. Therapy includes self-performed daily oral hygiene in combination with supra- and sub-gingival instrumentation. An adjunctive antimicrobial agent may improve the outcome.

Aims: To assess whether a chloramine (Perisolv®) has an adjunctive effect to non-surgical periodontal therapy and whether non-surgical periodontal therapy affects quality of life.

Material and methods: Thirty-eight patients were randomized to a test or a control group. Clinical indices were performed at baseline and at three and twelve months. In the test group, Perisolv® was applied initially and after the sub-gingival instrumentation in pathological pockets. Oral health-related quality of life was measured with the Oral Health Impact Profile (OHIP) instrument at baseline and twelve months.

Results: In both groups, an initial probing pocket depth (PPD) of > 4 mm and bleeding on probing (BOP) were statistically reduced (p < 0.002 and p < 0.002 respectively) at twelve months and after adjustment for Bonferroni. There were no significant differences between the test and the control group in terms of the number of PPD, BOP or plaque index, or in the mean OHIP score.

Conclusions: Chloramine did not have an adjunctive effect, but the overall therapy was significantly efficacious both clinically and in terms of quality of life.

Trial registration: Registered at www.

Clinicaltrials: gov:NCT05757921.

查看原文本刊更多论文

用氯胺辅助治疗牙周炎的龈上和龈下内固定-一项为期一年的随机临床试验研究。

牙周炎是一种细菌引起的疾病，因此控制微生物群是必要的。治疗包括自我进行日常口腔卫生，并结合牙龈上和牙龈下的仪器。一种辅助抗菌剂可以改善结果。目的:评估氯胺(Perisolv®)是否对非手术牙周治疗有辅助作用，以及非手术牙周治疗是否影响生活质量。材料与方法:38例患者随机分为试验组和对照组。在基线、3个月和12个月时进行临床指标测定。在试验组中，Perisolv®应用于病理袋龈下内固定的初始和之后。在基线和12个月时用口腔健康影响量表(OHIP)测量口腔健康相关生活质量。结果:两组患者初始探针袋深度(PPD)均为40mm，探针出血(BOP)均有统计学差异(p < 0.05)。结论:氯胺无辅助作用，但整体治疗在临床和生活质量方面均有显著疗效。试验报名:在www.clinicaltrials.gov注册:NCT05757921。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.