Group 2 innate lymphoid cells and their surrounding environment.

IF 5 3区 医学 Q2 IMMUNOLOGY
Maiko Naito, Atsushi Kumanogoh
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引用次数: 0

Abstract

Since the discovery of group 2 innate lymphoid cells (ILC2s) in 2010, subsequent studies have revealed their developmental pathways, mechanisms of activation and regulation, and immunological roles in tissue homeostasis and tissue-specific diseases in various organs. Although ILC2s are known to express tissue-specific features depending on where they reside, how the surrounding environment affects the functions of ILC2s remains to be fully elucidated. Recent histologic analyses revealed that ILC2s resides in specific perivascular regions in peripheral tissues with their function being controlled by the surrounding cells via cytokines, lipid mediators, neurotransmitters, and cell-cell interactions through surface molecules. This review summarizes the interactions between ILC2s and surrounding cells, including epithelial cells, neurons, immune cells, and mesenchymal cells, with the objective of promoting the development of novel diagnostic and therapeutic methods for ILC2-related diseases.

Abstract Image

Abstract Image

Abstract Image

2组先天淋巴样细胞及其周围环境。
自2010年发现2组先天淋巴样细胞(group 2 innate lymphoid cells, ILC2s)以来,后续研究揭示了其发育途径、活化调控机制以及在组织稳态和各器官组织特异性疾病中的免疫作用。虽然已知ILC2s根据其所在位置表达组织特异性特征,但周围环境如何影响ILC2s的功能仍有待充分阐明。最近的组织学分析表明,ILC2s存在于外周组织的特定血管周围区域,其功能受周围细胞通过细胞因子、脂质介质、神经递质和通过表面分子的细胞-细胞相互作用控制。本文综述了ILC2s与周围细胞(包括上皮细胞、神经元细胞、免疫细胞和间充质细胞)的相互作用,旨在促进ILC2s相关疾病的新诊断和治疗方法的发展。
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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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