C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2023-09-01 DOI:10.1016/j.nano.2023.102698

Olegi N. Kukaliia MD , Sergei V. Ageev MSc , Andrey V. Petrov MSc , Olga V. Kirik PhD , Dmitrii E. Korzhevskii PhD , Anatolii A. Meshcheriakov PhD , Anastasia A. Jakovleva PhD , Liudmila S. Poliakova PhD , Tatiana A. Novikova PhD , Maria E. Kolpakova PhD , Timur D. Vlasov DSc , Oleg E. Molchanov DSc , Dmitriy N. Maistrenko DSc , Igor V. Murin DSc , Vladimir V. Sharoyko DSc , Konstantin N. Semenov DSc

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Abstract

The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C₆₀-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C₆₀-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C₆₀-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.

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含l -精氨酸的C60加合物是治疗缺血性脑卒中的一种有前景的纳米材料

研究了水溶性富勒烯加合物c60 -精氨酸的生物相容性和生物活性。结果表明，该材料具有血液相容性，不具有细胞毒性和基因毒性，具有明显的抗氧化活性。并对水溶性富勒烯加合物在神经保护剂合成中的应用方向进行了展望。据推测，c60 -精氨酸加合物的保护作用机制与其抗氧化特性、穿透血脑屏障的能力以及l -精氨酸残基分解代谢释放一氧化氮有关，从而促进血管舒张。c60 -精氨酸加合物的作用与依达拉奉等抗氧化剂的作用进行了比较，依达拉奉在日本被批准用于治疗缺血性和出血性中风。

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.