The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Jingjing Chang , Di Song , Rongjun Yu
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引用次数: 0

Abstract

The hippocampus has long been considered a pivotal region implicated in both stress susceptibility and resilience. A wealth of evidence from animal and human studies underscores the significance of hippocampal functional connectivity with the ventromedial prefrontal cortex (vmPFC) in these stress-related processes. However, there remains a scarcity of research that explores and contrasts the roles of hippocampus-vmPFC connectivity in stress susceptibility and resilience when facing a real-life traumatic event from a prospective standpoint. In the present study, we investigated the contributions of undirected and directed connectivity between the hippocampus and vmPFC to stress susceptibility and resilience within the context of the COVID-19 pandemic. Our findings revealed that the left hippocampus-left vmPFC connectivity prior to the pandemic exhibited a negative correlation with both stress susceptibility and resilience. Specifically, individuals with stronger left hippocampus-left vmPFC connectivity reported experiencing fewer stress-related feelings during the outbreak period of the epidemic but displayed lower levels of stress resilience five months later. Our application of spectral dynamic causal modeling unveiled an additional inhibitory connectivity pathway from the left hippocampus to the left vmPFC in the context of stress susceptibility, which was notably absent in stress resilience. Furthermore, we observed a noteworthy positive association between self-inhibition of the vmPFC and stress susceptibility, with this effect proving substantial enough to predict an individual's susceptibility to stress; conversely, these patterns did not manifest in the realm of stress resilience. These findings enrich our comprehension of stress susceptibility and stress resilience and might have implications for innovative approaches to managing stress-related disorders.

海马体-腹内侧前额叶皮层静息状态连接在应激易感性和恢复力中的双刃剑:一项前瞻性研究
长期以来,海马体一直被认为是影响压力敏感性和恢复力的关键区域。来自动物和人类研究的大量证据强调了海马与腹内侧前额叶皮层(vmPFC)功能连接在这些应激相关过程中的重要性。然而,从前瞻性的角度探索和对比海马体- vmpfc连接在面对现实生活创伤事件时压力易感性和恢复力中的作用的研究仍然很少。在本研究中,我们研究了在COVID-19大流行背景下,海马和vmPFC之间的定向和定向连接对应激敏感性和恢复力的贡献。我们的研究结果显示,在大流行之前,左侧海马体-左侧vmPFC的连通性与压力敏感性和恢复力都呈负相关。具体来说,左侧海马体-左侧vmPFC连通性较强的个体报告说,在疫情爆发期间,与压力相关的感受较少,但五个月后表现出较低的压力恢复能力。我们应用谱动态因果模型揭示了应激易感性背景下从左侧海马体到左侧vmPFC的额外抑制连接通路,这在应激恢复力中是明显缺失的。此外,我们观察到vmPFC的自我抑制与压力易感性之间存在显著的正相关,这种影响足以预测个体对压力的易感性;相反,这些模式并没有在压力恢复能力领域表现出来。这些发现丰富了我们对压力易感性和压力恢复力的理解,并可能对管理压力相关疾病的创新方法产生影响。
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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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