Examining Phenotypic Differences in Gaze Avoidance Between Autism Spectrum Disorder and Fragile X Syndrome.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-11-01 DOI:10.1352/1944-7558-127.6.435

Ellen H Wilkinson, Tobias C Britton, Scott S Hall

引用次数: 2

Abstract

We examined potential phenotypic differences in eye gaze avoidance exhibited by boys with autism spectrum disorder (ASD) and boys with fragile X syndrome (FXS). In Study 1, the Eye Contact Avoidance Scale (ECAS) was administered to caregivers of boys aged 7-18 years with FXS (n = 148), ASD (n = 168), and mixed developmental disabilities (MDD; n = 128). In Study 2, subsets of boys with FXS (n = 31) and boys with ASD (n = 25) received a brief behavioral treatment probe to improve eye contact. Results showed that boys with FXS obtained significantly higher scores on the ECAS compared to boys with ASD and MDD. Exposure to the brief behavioral treatment probe resulted in significant decreases in scores for boys with FXS, but not for boys with ASD.

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自闭症谱系障碍和脆性X综合征凝视回避的表型差异研究。

我们研究了自闭症谱系障碍(ASD)男孩和脆性X染色体综合征(FXS)男孩在眼睛凝视回避方面的潜在表型差异。研究1对7-18岁FXS (n = 148)、ASD (n = 168)、混合性发育障碍(MDD;N = 128)。在研究2中，患有FXS的男孩(n = 31)和患有ASD的男孩(n = 25)接受了简短的行为治疗探针，以改善眼神交流。结果显示，FXS男孩的ECAS得分明显高于ASD和MDD男孩。暴露于简短的行为治疗探针导致FXS男孩的得分显著下降，但对ASD男孩没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.