Emerging plant proteins as nanocarriers of bioactive compounds

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2023-03-01 DOI:10.1016/j.jconrel.2023.01.069

Milad Hadidi , Chen Tan , Elham Assadpour , Mohammad Saeed Kharazmi , Seid Mahdi Jafari

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引用次数: 13

Abstract

The high prevalence of chronic illnesses, including cancer, diabetes, obesity, and cardiovascular diseases has become a growing concern for modern society. Recently, various bioactive compounds (bioactives) are shown to have a diversity of health-beneficial impacts on a wide range of disorders. But the application of these bioactives in food and pharmaceutical formulations is limited due to their poor water solubility and low bioaccessibility/bioavailability. Plant proteins are green alternatives for designing biopolymeric nanoparticles as appropriate nanocarriers thanks to their amphiphilic nature compatible with many bioactives and unique functional properties. Recently, emerging plant proteins (EPPs) are employed as nanocarriers for protection and targeted delivery of bioactives and also improving their stability and shelf-life. EPPs could enhance the solubility, stability, and bioavailability of bioactives by different types of delivery systems. In addition, the use of EPPs in combination with other biopolymers like polysaccharides was found to make a favorable wall material for food bioactives. This review article covers the various sources and importance of EPPs along with different encapsulation techniques of bioactives. Characterization of EPPs for encapsulation is also investigated. Furthermore, the focus is on the application of EPPs as nanocarriers for food bioactives.

Abstract Image

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新兴植物蛋白作为生物活性化合物的纳米载体

包括癌症、糖尿病、肥胖症和心血管疾病在内的慢性病的高患病率已成为现代社会日益关注的问题。最近，各种生物活性化合物（生物活性物质）被证明对多种疾病具有多种有益健康的影响。但由于其水溶性差、生物可及性/生物利用度低，这些生物活性物质在食品和药物配方中的应用受到限制。植物蛋白是设计生物聚合物纳米颗粒作为合适的纳米载体的绿色替代品，因为它们具有与许多生物活性物质相容的两亲性和独特的功能特性。最近，新兴的植物蛋白（EPP）被用作纳米载体，用于保护和靶向递送生物活性物质，并提高其稳定性和保质期。EPP可以通过不同类型的递送系统提高生物活性物质的溶解度、稳定性和生物利用度。此外，EPP与多糖等其他生物聚合物的结合使用被发现是一种用于食品生物活性物质的有利壁材料。这篇综述文章涵盖了EPP的各种来源和重要性，以及生物活性物质的不同封装技术。还研究了用于封装的EPP的特性。此外，重点是EPP作为食品生物活性物质的纳米载体的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.