Polyethylene glycol (PEG-400) as a recyclable and biodegradable reaction medium for green synthesis of 2-amino-4H-chromenes

Abstract

A helpful manufactured course to the one-pot green synthesis of 2-amino-4H-chromenes through a tandem Knoevenagel-Michael cyclocondensation reaction of aldehydes, malononitrile, and resorcinol in polyethylene glycol (PEG-400) as accessible and biodegradable media have been detailed. All responses are completed in a brief time and the items are gotten in fabulous yields. The striking highlights of this eco-friendly approach are biodegradable media, fabulous yields, simple work-up without requires for column chromatographic separation, and no poisonous organic solvents, evasion of harmful reagents, one-pot strategy, and effortlessness of operation. Additionally, PEG-400 is exceedingly steady and can be reused for four sequential runs without major basic changes or misfortune of movement, which has been exceptionally advantageous in tending to natural concerns.