Could Chronic Hypothermia in a Human Affect the Clock System?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.1086/722707

André Malan, Gerhard Heldmaier

引用次数: 0

Abstract

AbstractHibernation-like episodes would be particularly interesting for clinical and spatial use if they could be observed and induced in humans. As animal hibernation differs from hypothermia with its control by a temperature-dependent clock, we undertook to find evidence that human hypothermia might affect the circadian clock system. We revisited Siffre's 1962 abyss experiment. Deprived of temporal information and showing signs of chronic hypothermia, Siffre underestimated his stay underground by 22 d. We show that the temperature-dependent clock equation for classical hibernators accurately predicts Siffre's subjective times, and we list potential conditions to be further explored for inducing hibernation-like bouts in humans.

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慢性体温过低会影响生物钟吗?

如果能在人类中观察和诱导，这种类脑病发作将在临床和空间应用中特别有趣。由于动物冬眠与体温过低不同，体温过低是由温度依赖的生物钟控制的，因此我们致力于寻找人类体温过低可能影响生物钟系统的证据。我们重温了Siffre 1962年的深渊实验。由于缺乏时间信息和慢性体温过低的迹象，Siffre低估了他在地下的时间22天。我们表明，经典冬眠动物的温度依赖时钟方程准确地预测了Siffre的主观时间，我们列出了潜在的条件，需要进一步探索，以诱导人类冬眠样发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.