Distribution of blaCTX-M-gene variants in E. coli from different origins in Ecuador

Q2 Medicine

Medicine in Microecology Pub Date : 2023-10-31 DOI:10.1016/j.medmic.2023.100092

Xavier Valenzuela , Hayden Hedman , Alma Villagomez , Paul Cardenas , Joseph N.S. Eisenberg , Karen Levy , Lixin Zhang , Gabriel Trueba

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Abstract

The increasing abundance of extended spectrum β-lactamase (ESBL) genes in E. coli, and other commensal and pathogenic bacteria, endangers the utility of third or more recent generation cephalosporins, which are major tools for fighting deadly infections. The role of domestic animals in the transmission of ESBL carrying bacteria has been recognized, especially in low- and middle-income countries, however the horizontal gene transfer of these genes is difficult to assess. Here we investigate bla_CTX-M gene diversity (and flanking nucleotide sequences) in E. coli from chicken and humans, in an Ecuadorian rural community and from chickens in another location in Ecuador. The bla_CTX-M associated sequences in isolates from humans and chickens in the same remote community showed greater similarity than those found in E. coli in a chicken industrial operation 200 km away. Our study may provide evidence of bla_CTX-M transfer between chickens and humans in the community.

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厄瓜多尔不同来源大肠杆菌中blactx - m基因变异的分布

大肠杆菌和其他共生细菌和致病菌中扩展谱β-内酰胺酶(ESBL)基因的丰度不断增加，危及第三代或更近一代头孢菌素的使用，头孢菌素是对抗致命感染的主要工具。家畜在携带ESBL细菌传播中的作用已被认识到，特别是在低收入和中等收入国家，然而这些基因的水平基因转移难以评估。在这里，我们研究了来自厄瓜多尔农村社区的鸡和人的大肠杆菌中的blaCTX-M基因多样性(和侧翼核苷酸序列)，以及来自厄瓜多尔另一个地方的鸡。从同一偏远社区的人和鸡分离出的blaCTX-M相关序列与200公里外的养鸡场的大肠杆菌中发现的序列具有更大的相似性。本研究可能为社区鸡与人之间的blaCTX-M传播提供证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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