Application of stem cells in engineered vascular graft and vascularized organs

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI:10.1016/j.semcdb.2022.10.003

Shanlan Zhao , Qiao Zhang , Min Liu , Jiahui Du , Tingting Wang , Yanzhao Li , Wen Zeng

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引用次数: 3

Abstract

Recent studies report that stem cell therapies have been applied successfully to patients, This has increased anticipations that this regeneration strategy could be a potential method to treat a wide range of intractable diseases some day. Stem cells offer new prospects for the treatment of incurable diseases and for tissue regeneration and repairation because of their unique biological properties. Angiogenesis a key process in tissue regeneration and repairation. Vascularization of organs is one of the main challenges hindering the clinical application of engineered tissues. Efficient production of engineered vascular grafts and vascularized organs is of critical importance for regenerative medicine. In this review, we focus on the types of stem cells that are widely used in tissue engineering and regeneration, as well as their application of these stem cells in the construction of tissue-engineered vascular grafts and vascularization of tissue-engineered organs.

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干细胞在工程血管移植及血管化器官中的应用

最近的研究报告称，干细胞疗法已成功应用于患者，这增加了人们对这种再生策略有朝一日可能成为治疗各种棘手疾病的潜在方法的预期。干细胞由于其独特的生物学特性，为治疗不治之症以及组织再生和修复提供了新的前景。血管生成是组织再生和修复的关键过程。器官血管化是阻碍工程组织临床应用的主要挑战之一。高效生产工程化血管移植物和血管化器官对再生医学至关重要。在这篇综述中，我们重点介绍了在组织工程和再生中广泛使用的干细胞类型，以及这些干细胞在组织工程血管移植物构建和组织工程器官血管化中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.