Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI:10.1016/j.semcdb.2022.09.014

Bruno L. Marques , Giovana Figueiredo Maciel , Marcello R. Brito Júnior , Lucas D. Dias , Sérgio Scalzo , Anderson K. Santos , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Rodrigo R. Resende

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引用次数: 3

Abstract

The world population’s life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, microRNAs, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy.

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干细胞分化的调控机制:神经发生的生物技术应用

世界人口的预期寿命正在增长，老年常见的神经退行性疾病需要更有效的治疗。在这种情况下，神经干细胞（NSCs）对于神经系统功能的发展和维持是必不可少的，并且对神经退行性疾病具有广泛的治疗适用性。因此，了解所有控制NSC自我更新、分化和细胞信号传导的机制是必要的。这篇综述将涉及其中的一些方面，包括生长和转录因子、表观遗传学调节剂、微小RNA和细胞外基质成分的作用。此外，分化和转分化过程将被视为治疗策略，显示其对基于干细胞的治疗的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.