Organoids as a novel tool in modelling infectious diseases

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI:10.1016/j.semcdb.2022.09.003

Lucas Felipe de Oliveira , Daniel Mendes Filho , Bruno Lemes Marques , Giovana Figueiredo Maciel , Ricardo Cambraia Parreira , José Rodrigues do Carmo Neto , Priscilla Elias Ferreira Da Silva , Rhanoica Oliveira Guerra , Marcos Vinicius da Silva , Helton da Costa Santiago , Alexander Birbrair , Alexandre H. Kihara , Valdo José Dias da Silva , Talita Glaser , Rodrigo R. Resende , Henning Ulrich

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引用次数: 1

Abstract

Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue architecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host–infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments.

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类器官作为传染病建模的新工具

世界各地的传染病影响着人类健康，并具有重要的社会影响。迫切需要更好地了解传染病。体外和体内感染模型为目前对这些疾病的了解做出了显著贡献。类器官是一种类似组织结构和功能的多细胞培养系统，概括了人类疾病的许多特征，并阐明了呼吸和胃肠系统、中枢神经系统和皮肤中宿主-传染源相互作用的机制。在这里，我们讨论了类器官技术在建模发病机制、宿主反应和特征方面的适用性，这些技术可用于开发预防和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.