Mechanical Parameters Based on High-Speed Videoendoscopy of the Vocal Folds in Patients With Ectodermal Dysplasia

IF 2.4 4区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of Voice Pub Date : 2025-09-01 DOI:10.1016/j.jvoice.2023.02.027

Franziska Pelka, Maria Ensthaler, Olaf Wendler, Stefan Kniesburges, Anne Schützenberger, Marion Semmler

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引用次数: 0

Abstract

Objective

Patients suffering from ectodermal dysplasia (ED), which is an inherited disorder in the development of the ectodermal structures, have a significantly reduced expression of teeth, hair, sweat glands, and salivary glands in the respiratory tract including the larynx. Previous studies within the framework of the present project showed a significantly reduced saliva production and an impairment of the acoustic outcome in ED patients compared to the control group. However, until now, no statistically significant difference between EDs and controls could be found regarding vocal fold dynamics in the high-speed videoendoscopy (HSV) recordings using representative parameters on closure, symmetry, and periodicity. The aim of this study is to examine the role of tissue characteristics by means of objective mechanical parameters derived from HSV recordings.

Methods

This study includes 28 ED patients and 42 controls (no ED, healthy voice). The vocal fold oscillations were recorded by high-speed videoendoscopy (HSV@4kHz). Based on the dynamical measures of the glottal area waveform (GAW), objective glottal dynamic parameters associated with tissue properties like flexibility and stiffness were computed.

Results

The present evaluation displays a significant difference between male ED patients and male controls concerning the HSV-based mechanical parameters indicating reduced stiffness and increased deformability for the vocal folds of male ED patients. In contrast to strongly amplitude-dependent parameters, the primarily velocity-based parameters showed no statistically significant deviation.

Conclusions

The presented data provides the first promising indication toward the underlying causes on the laryngeal level leading to the voice conspicuities in ED patients. The significant difference concerning the mechanical parameters suggests a different composition of the extracellular matrix of the tissue of the vocal folds of ED patients compared to controls.

查看原文本刊更多论文

基于高速视频内窥镜的外胚层发育不良患者声带力学参数研究

目的外胚层发育不良（ED）是一种外胚层结构发育的遗传性疾病，患者在包括喉部在内的呼吸道中牙齿、毛发、汗腺和唾液腺的表达明显减少。在本项目框架内的先前研究表明，与对照组相比，ED患者的唾液分泌显著减少，声学结果受损。然而，到目前为止，在高速视频内窥镜（HSV）记录的声带动力学中，使用代表性参数的闭合性、对称性和周期性，ed和对照组之间没有统计学上的显著差异。本研究的目的是通过从HSV记录中获得的客观力学参数来检查组织特征的作用。方法本研究纳入ED患者28例，对照组42例（无ED，声音健康）。高速视频内窥镜（HSV@4kHz）记录声带振荡。基于声门面积波形（GAW）的动态测量，计算了与组织柔韧性、刚度等相关的客观声门动态参数。结果男性ED患者与男性对照组在基于hsv的力学参数上存在显著差异，表明男性ED患者声带刚度降低，可变形性增加。与强烈依赖振幅的参数相反，主要基于速度的参数没有统计学上显著的偏差。结论本文提供了第一个有希望的指示，表明在喉部水平导致ED患者声音显著。力学参数的显著差异表明ED患者声带组织的细胞外基质组成与对照组不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Voice 医学-耳鼻喉科学

CiteScore

4.00

自引率

13.60%

发文量

395

审稿时长

59 days

期刊介绍： The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.