Olfactory Dysfunction Following Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

IF 5.4 2区 心理学 Q1 NEUROSCIENCES
Neuropsychology Review Pub Date : 2023-12-01 Epub Date: 2022-09-07 DOI:10.1007/s11065-022-09563-2
Katherine Tai, Evelyn M Leland, Stella M Seal, Andrea L C Schneider, Nicholas R Rowan, Vidyulata Kamath
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引用次数: 0

Abstract

Objective: Reports of smell loss following traumatic brain injury (TBI) are a well-documented but understudied phenomenon. Given the broad consequences of olfactory loss, we characterized psychophysical olfactory dysfunction in individuals with moderate to severe TBI using systematic review and meta-analytic methods.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol, five databases (PubMed, EMBASE, Cochrane Library, Web of Science, Scopus) were reviewed for studies investigating olfactory dysfunction in persons with moderate to severe TBI. Of the 5,223 studies reviewed, 19 met our inclusion criteria for the systematic review and 11 met inclusion criteria for meta-analysis. We calculated effect sizes (Hedges' g) to characterize the degree of olfactory dysfunction between patients with moderate to severe TBI and controls.

Results: A total of 951 moderate-severe TBI patients from 19 studies were included in the systematic review, which largely demonstrated poorer olfactory psychophysical performances in this patient population. Meta-analysis demonstrated a large effect size for olfactory dysfunction in moderate-severe TBI relative to healthy controls (g=-2.43, 95%CI: -3.16 < δ<-1.69). The magnitude of the effect was moderated by age and patient sex, with larger effect sizes associated with older age (following exclusion of a pediatric population) and larger compositions of women in the patient group.

Conclusion: Moderate to severe TBI is associated with prominent olfactory dysfunction. Significant research gaps remain regarding the mechanism, recovery and natural history of olfactory dysfunction following moderate to severe TBI, which has significant clinical implications for the identification and treatment for those with post-traumatic olfactory dysfunction.

中度至重度创伤性脑损伤后的嗅觉功能障碍:系统回顾与元分析》。
目的:有关创伤性脑损伤(TBI)后嗅觉丧失的报道屡见不鲜,但对这一现象的研究却不足。鉴于嗅觉丧失的广泛后果,我们采用系统综述和荟萃分析方法对中重度创伤性脑损伤患者的心理物理嗅觉功能障碍进行了描述:按照《系统综述和荟萃分析首选报告项目》(PRISMA)协议,我们查阅了五个数据库(PubMed、EMBASE、Cochrane Library、Web of Science、Scopus)中有关中重度创伤性脑损伤患者嗅觉功能障碍的研究。在查阅的 5,223 项研究中,19 项符合我们的系统综述纳入标准,11 项符合荟萃分析纳入标准。我们计算了效应大小(Hedges'g)来描述中重度创伤性脑损伤患者与对照组之间嗅觉功能障碍的程度:系统综述共纳入了 19 项研究中的 951 名中重度创伤性脑损伤患者,这些研究大多表明这类患者的嗅觉心理物理表现较差。元分析表明,与健康对照组相比,中重度 TBI 患者嗅觉功能障碍的效应大小较大(g=-2.43,95%CI:-3.16 结论:中度至重度创伤性脑损伤与突出的嗅觉功能障碍有关。关于中度至重度 TBI 后嗅觉功能障碍的机制、恢复和自然史的研究仍存在重大差距,这对识别和治疗创伤后嗅觉功能障碍患者具有重要的临床意义。
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来源期刊
Neuropsychology Review
Neuropsychology Review 医学-神经科学
CiteScore
11.00
自引率
1.70%
发文量
36
期刊介绍: Neuropsychology Review is a quarterly, refereed publication devoted to integrative review papers on substantive content areas in neuropsychology, with particular focus on populations with endogenous or acquired conditions affecting brain and function and on translational research providing a mechanistic understanding of clinical problems. Publication of new data is not the purview of the journal. Articles are written by international specialists in the field, discussing such complex issues as distinctive functional features of central nervous system disease and injury; challenges in early diagnosis; the impact of genes and environment on function; risk factors for functional impairment; treatment efficacy of neuropsychological rehabilitation; the role of neuroimaging, neuroelectrophysiology, and other neurometric modalities in explicating function; clinical trial design; neuropsychological function and its substrates characteristic of normal development and aging; and neuropsychological dysfunction and its substrates in neurological, psychiatric, and medical conditions. The journal''s broad perspective is supported by an outstanding, multidisciplinary editorial review board guided by the aim to provide students and professionals, clinicians and researchers with scholarly articles that critically and objectively summarize and synthesize the strengths and weaknesses in the literature and propose novel hypotheses, methods of analysis, and links to other fields.
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