Predictive value of C-reactive protein/albumin ratio for no-reflow in patients with non-ST-elevation myocardial infarction.

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Aydın Rodi Tosu, Tufan Çinar, Muhsin Kalyoncuoğlu, Halil İbrahim Biter, Sinem Çakal, Beytullah Çakal, Murat Selçuk, Erdal Belen, Mehmet Mustafa Can
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Abstract

Introduction: The focus of this research was to explore the link between CRP (C-reactive protein) /albumin ratio (CAR), a novel inflammatory response marker, and no-reflow (NR) phenomena in non-ST elevation myocardial infarction (non-STEMI) patients during percutaneous coronary intervention (PCI). Methods: The current study recruited 209 non-STEMI participants who underwent PCI. The patients were divided into two groups based on their post-intervention Thrombolysis in Myocardial Infarction (TIMI) flow grade; those with and without NR. Results: In all, 30 non-STEMI patients (6.9%) had NR after PCI. CAR values were substantially greater in the NR group. The CAR was identified to be a determinant of the NR (OR: 1.250, 95% CI: 1.033-1.513, P=0.02), although CRP and albumin were not independently related with NR in the multivariate analysis. In our investigation, low density lipoprotein-cholesterol levels and high thrombus burden were also predictors of the occurrence of NR. According to receiver operating characteristic curve evaluation, the optimal value of CAR was>1.4 with 60% sensitivity and 47% specificity in detecting NR in non-STEMI patients following PCI. Conclusion: To the best of knowledge, this is the first investigation to demonstrate that the CAR, a new and useful inflammatory marker, can be utilized as a predictor of NR in patients with non-STEMI prior to PCI.

Abstract Image

c反应蛋白/白蛋白比值对非st段抬高型心肌梗死患者无血流的预测价值。
本研究的重点是探讨新型炎症反应标志物CRP (c -反应蛋白)/白蛋白比(CAR)与非st段抬高型心肌梗死(non-STEMI)患者经皮冠状动脉介入治疗(PCI)期间无血流再流(NR)现象之间的关系。方法:本研究招募了209名接受PCI治疗的非stemi患者。根据干预后心肌梗死溶栓(TIMI)血流等级将患者分为两组;结果:30例非stemi患者(6.9%)PCI术后出现NR。NR组的CAR值明显更高。CAR被认为是NR的一个决定因素(OR: 1.250, 95% CI: 1.033-1.513, P=0.02),尽管在多变量分析中CRP和白蛋白与NR没有独立的相关性。在我们的研究中,低密度脂蛋白-胆固醇水平和高血栓负荷也是NR发生的预测因素。根据受试者工作特征曲线评价,对于PCI后非stemi患者,CAR的最佳值为>1.4,灵敏度为60%,特异性为47%。结论:据我们所知,这是第一个研究表明,CAR是一种新的、有用的炎症标志物,可以作为PCI前非stemi患者NR的预测指标。
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来源期刊
Journal of Cardiovascular and Thoracic Research
Journal of Cardiovascular and Thoracic Research CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.00
自引率
0.00%
发文量
22
审稿时长
7 weeks
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