Experimental Infection in Rabbits Evoked by Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli and Klebsiella pneumoniae Treated with Gentamicin, Amikacin and Sisomicin

Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie Pub Date : 1980-08-01 DOI:10.1016/S0172-5599(80)80039-3

J. Jeljaszewicz , K. Wlodarczak , W. Bis , A. Kazanowski , P. Kuzniewski , J. Molska

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引用次数: 1

Abstract

Rabbits were infected with freshly isolated strains of Ps. aeruginosa, P. mirabilis, E. coli or K. pneumoniae and treated with gentamicin, amikacin or sisomicin in a controlled study. Therapeutic results were evaluated by survival of animals and viable counts of etiologic bacteria in several tissues after sacrification of treated animals at the same time. Sisomicin was the drug of choice for Ps. aeruginosa and P. mirabilis infections, when compared with amikacin and gentamicin. Its action is practically equal to that of amikacin in K. pneumoniae infection. Sisomicin appeared less active in E. coli infections than amikacin, but was superior to gentamicin.

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庆大霉素、阿米卡星和西索米星治疗铜绿假单胞菌、奇异变形杆菌、大肠杆菌和肺炎克雷伯菌诱发兔实验感染

兔感染新分离的铜绿假单胞菌、神奇假单胞菌、大肠杆菌或肺炎克雷伯菌，并用庆大霉素、阿米卡星或西索霉素进行对照研究。治疗结果是通过动物的存活率和同时牺牲治疗动物后几个组织中病原细菌的活菌计数来评估的。与阿米卡星和庆大霉素相比，西索米星是铜绿假单胞菌和奇异假单胞菌感染的首选药物。它在肺炎克雷伯菌感染中的作用几乎等于阿米卡星。西索米星对大肠杆菌感染的活性低于阿米卡星，但优于庆大霉素。

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Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie

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