Phytochemical constituents of Dracaena mahatma leaves and their anti-bacterial, anti-oxidant and anti-inflammatory significance

Biotechnology Research and Innovation Pub Date : 2018-01-01 DOI:10.1016/j.biori.2018.09.002

Saranya Shankar , Sugashini Settu , Gayathri Segaran , Ranjitha Dhevi V. Sundar , Lokesh Ravi

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引用次数: 8

Abstract

The present study aims to analyze the antimicrobial, antioxidant and anti-inflammatory activity of Dracaena mahatma leaf extract. Qualitative phytochemical screening of leaf powder confirmed the presence of tannins, alkaloids, phenols, terpenoids, sterols, triterpenes and anthraquinone glycosides. GC-MS analysis of methanolic extract suggested the presence of 2 unknown compounds and 8 known phytochemicals, of which benzene-(1,6-hexanediylidene)tetrakis constituted a maximum percentage of the crude extract. The total phenolic content of the crude extract was found to be 32.9 ± 0.002 GAE/g. Crude extract demonstrated 90% antioxidant activity in DPPH assay at 100 μg/ml concentration and also demonstrated significant antioxidant activity in FRAP assay at 100 μg/ml concentration. The crude extract did not show any antagonism against fungal pathogens Aspergillus niger and Aspergillus flavus. Crude extract demonstrated significant antibacterial activity against 5 studied pathogen, with the highest antagonism against Escherichia coli with a zone of inhibition of 22 mm at 10 mg/well concentration.

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龙血树叶的植物化学成分及其抗菌、抗氧化和抗炎意义

本研究旨在分析龙血树叶提取物的抗菌、抗氧化和抗炎活性。对叶粉进行定性植物化学筛选，证实其含有单宁、生物碱、酚类、萜类、甾醇、三萜和蒽醌苷。甲醇提取物的GC-MS分析表明存在2种未知化合物和8种已知植物化学物质，其中苯-(1,6-己二烯)四联基占粗提取物的最大百分比。粗提物总酚含量为32.9±0.002 GAE/g。粗提物在100 μg/ml浓度的DPPH实验中显示出90%的抗氧化活性，在100 μg/ml浓度的FRAP实验中也显示出显著的抗氧化活性。粗提物对真菌病原菌黑曲霉和黄曲霉无拮抗作用。粗提物对5种病原菌均有显著的抑菌活性，在10 mg/孔浓度下，对大肠杆菌的抑菌作用最大，抑菌带达22 mm。

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Biotechnology Research and Innovation

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