{"title":"Biological functions of miR-590 and its role in carcinogenesis","authors":"Yang Dong, Guang-Bin Qiu","doi":"10.1016/j.flm.2017.11.002","DOIUrl":null,"url":null,"abstract":"<div><p>MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR) inducing translation inhibition or mRNA degradation of their targets. MiR-590 plays a key role in cellular proliferation, differentiation, apoptosis and aging, and participates in development and progress of many diseases including cancer. Furthermore, miR-590 has different functions as a tumor suppressor or an oncogene by targeting various genes. This review is to summarize the structure, biological function and role of the miR-590 gene.</p></div>","PeriodicalId":100555,"journal":{"name":"Frontiers in Laboratory Medicine","volume":"1 4","pages":"Pages 173-176"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.flm.2017.11.002","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2542364917301115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
MicroRNAs (miRNAs), a class of non-coding single small RNAs transcribed from Eukaryotic genes, regulate gene expression at post-transcriptional levels via binding to 3′-untranslation region (3′ UTR) inducing translation inhibition or mRNA degradation of their targets. MiR-590 plays a key role in cellular proliferation, differentiation, apoptosis and aging, and participates in development and progress of many diseases including cancer. Furthermore, miR-590 has different functions as a tumor suppressor or an oncogene by targeting various genes. This review is to summarize the structure, biological function and role of the miR-590 gene.
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