Monkeypox Virus Infections in Humans.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2022-12-21 Epub Date: 2022-11-14 DOI:10.1128/cmr.00092-22
Sameer Elsayed, Lise Bondy, William P Hanage
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引用次数: 16

Abstract

Human monkeypox is a viral zoonosis endemic to West and Central Africa that has recently generated increased interest and concern on a global scale as an emerging infectious disease threat in the midst of the slowly relenting COVID-2019 disease pandemic. The hallmark of infection is the development of a flu-like prodrome followed by the appearance of a smallpox-like exanthem. Precipitous person-to-person transmission of the virus among residents of 100 countries where it is nonendemic has motivated the immediate and widespread implementation of public health countermeasures. In this review, we discuss the origins and virology of monkeypox virus, its link with smallpox eradication, its record of causing outbreaks of human disease in regions where it is endemic in wildlife, its association with outbreaks in areas where it is nonendemic, the clinical manifestations of disease, laboratory diagnostic methods, case management, public health interventions, and future directions.

人类猴痘病毒感染。
人类猴痘是西非和中非流行的一种病毒性人畜共患病,最近在2019冠状病毒病大流行缓慢缓和的背景下,作为一种新出现的传染病威胁,在全球范围内引起了越来越多的关注和关注。感染的标志是出现类似流感的前驱症状,随后出现类似天花的症状。该病毒在100个非流行国家的居民中迅速发生人际传播,促使立即广泛实施公共卫生对策。在这篇综述中,我们讨论了猴痘病毒的起源和病毒学,它与天花根除的联系,它在野生动物流行地区引起人类疾病暴发的记录,它与非流行地区暴发的关系,疾病的临床表现,实验室诊断方法,病例管理,公共卫生干预和未来的方向。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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