Erythrocyte-based Drug Delivery: How Far from Clinical Application?

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201820666230320103529

Yuan Jiang, Yi Yuan, Feng Peng, Yi Deng, Chao Ren, Chongzhi Liu, Hai Dong, Tao Tu

引用次数: 0

Abstract

Erythrocytes are responsible for delivering oxygen throughout the body. They have become suitable drug carriers due to outstanding advantages, such as a long lifespan in circulation, high biosafety, and low immunogenicity. Although erythrocyte-based drug delivery has good application prospects and has become a research hotspot in related fields, the application of erythrocyte-based drug delivery systems is rare in the clinic now. In this review, we discuss the characteristics of erythrocytes, diverse drug-loading approaches, and research progress of erythrocyte-based drug delivery systems. Finally, we explore the challenges of erythrocyte-based drug delivery in clinical application.

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红细胞给药:离临床应用还有多远?

红细胞负责将氧气输送到全身。它们具有循环寿命长、生物安全性高、免疫原性低等突出优点，已成为合适的药物载体。尽管红细胞给药系统具有良好的应用前景，已成为相关领域的研究热点，但目前临床上红细胞给药物系统的应用尚不多见。在这篇综述中，我们讨论了红细胞的特性、不同的载药方法以及基于红细胞的药物递送系统的研究进展。最后，我们探讨了红细胞给药在临床应用中的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.