Osteonecrosi spontanea dei mascellari in relazione all’assunzione di bisfosfonati endovenosi: caso clinico

Italian Oral Surgery Pub Date : 2012-12-01 DOI:10.1016/j.ios.2011.09.002

F. Carini , K. Pavanello , V. Pisapia , G. Gatti , G. Porcaro

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Abstract

Objectives

Osteonecrosis of the jaw (ONJ) is one of the multiple side effects of bisphosphonate therapy. The incidence of ONJ among patients receiving intravenous (IV) bisphosphonates exceeds that recorded in patients treated with oral bisphosphonates. We report a case of spontaneous ONJ related to intravenous administration of bisphosphonates.

Materials and methods

We describe a case of spontaneous mandibular osteonecrosis in a female patient who underwent dental surgery before beginning therapy with bisphosphonates.

Results

The patient's bone exposure was resolved, which illustrates that prompt, effective treatment can produce cures in patients with ONJ on IV bisphosphonate therapy and with other risk factors.

Conclusions

Patients scheduled to undergo IV bisphosphonate therapy should be informed of its potential risks and treated in accordance with a precise therapeutic procedure that includes a dental evaluation before treatment. This approach ensures rapid resolution of possible treatment-related complications via consultation and collaboration of various medical specialists.

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与静脉注射双磷酸盐有关的下颌骨自发性骨坏死:临床病例

目的探讨颌骨骨坏死(ONJ)是双膦酸盐治疗的副作用之一。接受静脉注射(IV)双膦酸盐治疗的患者的ONJ发生率超过口服双膦酸盐治疗的患者。我们报告一例自发性ONJ与静脉注射双膦酸盐有关。材料和方法我们描述了一例自发性下颌骨坏死的女性患者，她在开始用双磷酸盐治疗前接受了牙科手术。结果患者的骨暴露得到了解决，说明在静脉注射双膦酸盐治疗和其他危险因素的情况下，及时有效的治疗可以使ONJ患者痊愈。结论接受静脉注射双膦酸盐治疗的患者应了解其潜在风险，并按照精确的治疗程序进行治疗，包括治疗前的牙科评估。这种方法确保通过各种医学专家的咨询和合作，快速解决可能的治疗相关并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Italian Oral Surgery

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