Exploring the Lipid World Hypothesis: A Novel Scenario of Self-Sustained Darwinian Evolution of the Liposomes.

IF 3.5 3区 物理与天体物理 Q2 ASTRONOMY & ASTROPHYSICS
Astrobiology Pub Date : 2023-03-01 Epub Date: 2023-01-30 DOI:10.1089/ast.2021.0161
Vladimir Subbotin, Gennady Fiksel
{"title":"Exploring the Lipid World Hypothesis: A Novel Scenario of Self-Sustained Darwinian Evolution of the Liposomes.","authors":"Vladimir Subbotin, Gennady Fiksel","doi":"10.1089/ast.2021.0161","DOIUrl":null,"url":null,"abstract":"<p><p>According to the Lipid World hypothesis, life on Earth originated with the emergence of amphiphilic assemblies in the form of lipid micelles and vesicles (liposomes). However, the mechanism of appearance of the information molecules (ribozymes/RNA) accompanying that process, considered obligatory for Darwinian evolution, is unclear. We propose a novel scenario of self-sustained Darwinian evolution of the liposomes driven by ever-present natural phenomena: solar UV radiation, day/night cycle, gravity, and the formation of liposomes in an aqueous media. The central tenet of this scenario is the liposomes' encapsulation of the heavy solutes, followed by their gravitational submerging in the water. The submerged liposomes, being protected from the damaging UV radiation, acquire the longevity necessary for autocatalytic replication of amphiphiles, their mutation, and the selection of those amphiphilic assemblies that provide the greatest membrane stability. These two sets of adaptive compositional information (heavy content and amphiphilic assemblies design) generate a population of liposomes with self-replication/reproduction properties, which are amendable to mutation, inheritance, and selection, thereby establishing Darwinian progression. Temporary and spatial expansion of this liposomal population will provide the basis for the next evolutionary step-a transition of accidentally entrapped RNA precursor molecules into complex functional molecules, such as ribozymes/RNA.</p>","PeriodicalId":8645,"journal":{"name":"Astrobiology","volume":"23 3","pages":"344-357"},"PeriodicalIF":3.5000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986030/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Astrobiology","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1089/ast.2021.0161","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ASTRONOMY & ASTROPHYSICS","Score":null,"Total":0}
引用次数: 0

Abstract

According to the Lipid World hypothesis, life on Earth originated with the emergence of amphiphilic assemblies in the form of lipid micelles and vesicles (liposomes). However, the mechanism of appearance of the information molecules (ribozymes/RNA) accompanying that process, considered obligatory for Darwinian evolution, is unclear. We propose a novel scenario of self-sustained Darwinian evolution of the liposomes driven by ever-present natural phenomena: solar UV radiation, day/night cycle, gravity, and the formation of liposomes in an aqueous media. The central tenet of this scenario is the liposomes' encapsulation of the heavy solutes, followed by their gravitational submerging in the water. The submerged liposomes, being protected from the damaging UV radiation, acquire the longevity necessary for autocatalytic replication of amphiphiles, their mutation, and the selection of those amphiphilic assemblies that provide the greatest membrane stability. These two sets of adaptive compositional information (heavy content and amphiphilic assemblies design) generate a population of liposomes with self-replication/reproduction properties, which are amendable to mutation, inheritance, and selection, thereby establishing Darwinian progression. Temporary and spatial expansion of this liposomal population will provide the basis for the next evolutionary step-a transition of accidentally entrapped RNA precursor molecules into complex functional molecules, such as ribozymes/RNA.

Abstract Image

Abstract Image

Abstract Image

探索脂质世界假说:脂质体自我持续达尔文进化的新情景。
根据 "脂质世界假说",地球上的生命起源于脂质胶束和囊泡形式的两亲集合体(脂质体)。然而,伴随着这一过程出现的信息分子(核糖酶/核糖核酸)被认为是达尔文进化论的必备条件,但其出现机制尚不清楚。在太阳紫外线辐射、昼夜循环、重力以及脂质体在水介质中的形成等无处不在的自然现象的驱动下,我们提出了一种脂质体自我持续达尔文进化的新方案。这一设想的核心原理是脂质体包裹重溶质,然后在重力作用下沉入水中。浸入水中的脂质体受到保护,不会受到紫外线辐射的伤害,从而获得了两亲性物质自催化复制、突变和选择两亲性集合体所需的长寿命,从而提供了最大的膜稳定性。这两组适应性成分信息(重金属含量和两亲集合体设计)产生了具有自我复制/再生产特性的脂质体群体,这些脂质体可进行变异、遗传和选择,从而建立起达尔文式的进展。这种脂质体群体的临时和空间扩展将为下一步进化奠定基础--意外夹带的 RNA 前体分子转变为复杂的功能分子,如核糖酶/RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Astrobiology
Astrobiology 生物-地球科学综合
CiteScore
7.70
自引率
11.90%
发文量
100
审稿时长
3 months
期刊介绍: Astrobiology is the most-cited peer-reviewed journal dedicated to the understanding of life''s origin, evolution, and distribution in the universe, with a focus on new findings and discoveries from interplanetary exploration and laboratory research. Astrobiology coverage includes: Astrophysics; Astropaleontology; Astroplanets; Bioastronomy; Cosmochemistry; Ecogenomics; Exobiology; Extremophiles; Geomicrobiology; Gravitational biology; Life detection technology; Meteoritics; Planetary geoscience; Planetary protection; Prebiotic chemistry; Space exploration technology; Terraforming
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信