Preparation of solid dispersion of Dushen decoction and establishment of its evaluation method

Abstract

The preparation technology of Dushen decoction solid dispersion (SD) was determined by analyzing the preparation method, carrier type, and carrier ratio. The quality evaluation method was established by infrared analysis spectrometry and differential scanning calorimetry. By using poloxamer 188 as the carrier material and a 1:8 optimal loading ratio, the Dushen decoction SD prepared by the melting method had a better dissolution, and the preparation process was reproducible. The Dushen decoction SD was also highly uniformly dispersed in the carrier material (poloxamer 188), and the mixing mode of Dushen decoction and poloxamer 188 was physical rather than chemical. The dissolution rate of the Dushen decoction SD was nearly 16 times higher than that in the traditional dosage form of Dushen decoction. Therefore, by preparing new formulations of Dushen decoction and establishing quality evaluation methods, a scientific basis can be obtained for follow-up in vivo and preclinical investigation.