Semen quality changes during infection and recovery phases of mild-to-moderate COVID-19 in reproductive-aged patients: a prospective case series.

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2023-01-19 DOI:10.1186/s12610-022-00175-7

Nasreldin Mohammed, Mostafa Kamel, Rabea Ahmed Gadelkareem, Mohammed Ali Zarzour, Adel Kurkar, Ahmed Mohammed Abdel-Moniem, Hosny Behnsawy

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引用次数: 4

Abstract

Background: Despite the documented effects of the coronavirus disease 2019 (COVID-19) on spermatogenesis, the reversibility of these effects is uncertain. We aimed to assess the changes of sperm quality between the infection and recovery phases of COVID-19 in reproductive-aged men. The semen quality of men with mild-to-moderated COVID-19 (defined by the degrees of symptoms and chest involvement on computed tomography) was studied during October, 2020-May, 2021 at our hospital. Two semen samples were analyzed at timings estimated to represent spermatogenic cycles during the infection and recovery phases of COVID-19.

Results: A total of 100 patients were included with mean ± SD (range) age of 24.6 ± 3.3 (21-35) years. During infection, 33% of patients had abnormal semen quality. However, a significant reduction was found in this abnormality from 33 to 11% (P < 0.001) after recovery from infection. In a comparison of the two semen analyses, there were significant improvements in the mean values of sperm progressive motility (P =0.043) and normal morphology (P < 0.001). However, the mean sperm concentration showed a statistically insignificant increase (P = 0.844).

Conclusions: In reproductive-aged patients with mild-to-moderate COVID-19, the effects on seminal quality were recoverable, represented by significant improvements in the means of progressive sperm motility and normal morphology between the infection and recovery phases of COVID-19.

Trial registration: ClinicalTrials, NCT04595240 .

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育龄患者轻至中度COVID-19感染和恢复阶段精液质量变化:前瞻性病例系列

背景:尽管有文献记载了2019冠状病毒病(COVID-19)对精子发生的影响，但这些影响的可逆性尚不确定。我们的目的是评估育龄男性COVID-19感染和恢复阶段之间精子质量的变化。研究了2020年10月至2021年5月期间我院轻至中度COVID-19男性(以症状程度和胸部ct受累程度定义)的精液质量。在估计代表COVID-19感染和恢复阶段的生精周期的时间对两个精液样本进行了分析。结果:共纳入100例患者，平均±SD(范围)年龄24.6±3.3(21-35)岁。感染期间，33%的患者精液质量异常。然而，在感染恢复后，这种异常从33%显著减少到11% (P < 0.001)。在两种精液分析的比较中，精子进行性活动力的平均值(P =0.043)和正常形态(P < 0.001)有显著改善。而平均精子浓度升高无统计学意义(P = 0.844)。结论:在轻中度COVID-19育龄患者中，对精子质量的影响是可恢复的，从感染到恢复阶段，精子运动能力和形态正常均有显著改善。试验注册:ClinicalTrials, NCT04595240。

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.