Antidyslipidaemic effect of Aegle marmelos Linn. fruit on Isoproterenol induced myocardial injury in rats

Abstract

The present study was designed to verify the antidyslipidemic effect of Aegle marmelos Linn. unripe fruit aqueous extract (AMUFAEt) against isoproterenol (IPL) induced cardiac stressed rats. Rats were divided into four groups (of six each): group I of healthy controls, group II of AMUFAEt treated (150 mg/kg body weight, for 45 days), group III of IPL treated rats (85 mg/kg body weight, once a day for 2 days) and group IV of AMUFAEt treated (150 mg/kg body weight, for 45days) and then IPL administered. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and phospholipids (PL) was significantly increased, while the levels of high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) decreased in serum of IPL treated rats. In AMUFAEt pretreated rats the dyslipidaemic effects of IPL were compensated to near normal levels. Blood glucose, protein levels were not significantly altered. The study shows that the extract has significant antidyslipidaemic effect.