Functional Microparticles – “LEGO” for Printable Bioelectronics Richard Newell

Rodtichoti Wannapob , Mikhail Vagin , Yu Liu , Anthony P.F. Turner , Mak Wing Cheung
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Abstract

The current trend towards flexible and light-weight portable electronic devices has raised the profile of the emerging field of printed electronics. Printable organic electronic devices provide a high-throughput and cost-effective approach for the fabrication of distributed healthcare devices, which will meet new market needs. Here, we present an innovative modular approach for the design and fabrication of printable biosensors. A “LEGO” style approach comprising various colloidal building blocks, such as conducting polymer-based microparticles and biopolymer-based microparticles (e.g. enzymes and antibodies) with well-defined and tunable nano-scale morphology, electrochemical behaviours and catalytic functions, were fabricated for the development of printable biosensors. Assembly of the printable biosensors can be performed simply by mixing various microparticles delivering the desired conductivity, capacitance, catalytic and affinity functions, followed by solvent-free printing of the microparticle mixture onto a substrate. The conductivity, capacitance and signal response of the printable biosensors were characterised. This modular approach allows high flexibility for the design for biosensors, as well as better integration between conducting polymers and biomolecules for the development of biosensors. As a proof-of-concept, a mediated glucose biosensor based on printable microparticles was developed and showed a high sensitivity of 2 mA (M cm2)-1.

功能微粒——可打印生物电子学的“乐高”
当前趋向于柔性和轻量化便携式电子设备的趋势已经提高了新兴印刷电子领域的知名度。可打印有机电子器件为分布式医疗设备的制造提供了高通量和高成本效益的方法,这将满足新的市场需求。在这里,我们提出了一种创新的模块化方法来设计和制造可打印的生物传感器。一种“乐高”式的方法,包括各种胶体构建块,如导电聚合物微颗粒和生物聚合物微颗粒(如酶和抗体),具有明确的和可调的纳米级形态,电化学行为和催化功能,用于开发可打印的生物传感器。可打印生物传感器的组装可以简单地通过混合各种微颗粒来完成,这些微颗粒具有所需的电导率、电容、催化和亲和功能,然后将微颗粒混合物无溶剂打印到基板上。对可打印生物传感器的电导率、电容和信号响应进行了表征。这种模块化方法为生物传感器的设计提供了高度的灵活性,也为生物传感器的开发提供了导电聚合物和生物分子之间更好的整合。作为概念验证,基于可打印微粒的介导葡萄糖生物传感器被开发出来,并显示出2 mA (M cm2)-1的高灵敏度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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