Olanzapine treatment of lactating females causes testicular atrophy in prepuberal rat offspring.

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnic & Histochemistry Pub Date : 2023-04-01 DOI:10.1080/10520295.2022.2150314

Luiz André Rodrigues Lima, Sandra Maria Torres, Simone Regina Barros Macêdo, Fernanda das Chagas Angelo Mendes Tenorio, Bruno Mendes Tenorio, Valdemiro Amaro da Silva Junior

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引用次数: 1

Abstract

The antipsychotic drug, olanzapine, is prescribed for postpartum psychosis. Possible adverse effects on fertility of offspring are unclear. We investigated the effects of administering olanzapine via lactation on testicular development and endocrine function of prepuberal male rats. Olanzapine was administered to mothers at 2.5, 5 or 10 mg/kg. We found in male offspring increased body weight, decreased gonadosomatic index, testicular weight and epididymal weight. The volume of seminiferous tubules, seminiferous epithelium, Leydig cells, intertubule tissue and lymphatic space was reduced in rat pups exposed to olanzapine. Tubule diameter and length, seminiferous epithelium height, Leydig cell size and nuclear diameter also were reduced. Testosterone levels were reduced in the groups exposed to olanzapine, while prolactin levels were increased. We observed histopathology in testes of animals whose mothers had been treated with 2.5 mg/kg olanzapine; more severe pathology was observed in offspring whose mothers were administered higher doses. Administration of olanzapine to mothers during lactation produced testicular and endocrine pathology in prepuberal rats in a dose-dependent manner.

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奥氮平治疗哺乳期雌性引起青春期前大鼠后代睾丸萎缩。

抗精神病药物奥氮平是治疗产后精神病的处方药。对后代生育能力可能产生的不利影响尚不清楚。本实验研究了哺乳期给药奥氮平对青春期前雄性大鼠睾丸发育和内分泌功能的影响。奥氮平以2.5、5或10 mg/kg的剂量给予母亲。我们发现雄性后代体重增加，性腺指数、睾丸重量和附睾重量下降。奥氮平使精小管、精小上皮、间质细胞、精小管间组织和淋巴间隙的体积减小。小管直径和长度、精原上皮高度、间质细胞大小和核直径均减小。暴露于奥氮平组的睾酮水平降低，而催乳素水平升高。我们观察了实验组小鼠睾丸的组织病理学变化，实验组小鼠的母亲给药2.5 mg/kg奥氮平;母亲被给予较高剂量的后代观察到更严重的病理。哺乳期给予奥氮平对青春期前大鼠的睾丸和内分泌有剂量依赖性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.