Tuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies.

IF 19 1区 医学 Q1 MICROBIOLOGY
Jan Heyckendorf, Sophia B Georghiou, Nicole Frahm, Norbert Heinrich, Irina Kontsevaya, Maja Reimann, David Holtzman, Marjorie Imperial, Daniela M Cirillo, Stephen H Gillespie, Morten Ruhwald
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引用次数: 16

Abstract

Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a global public health threat. A significant challenge for TB control efforts has been the monitoring of TB therapy and determination of TB treatment success. Current recommendations for TB treatment monitoring rely on sputum and culture conversion, which have low sensitivity and long turnaround times, present biohazard risk, and are prone to contamination, undermining their usefulness as clinical treatment monitoring tools and for drug development. We review the pipeline of molecular technologies and assays that serve as suitable substitutes for current culture-based readouts for treatment response and outcome with the potential to change TB therapy monitoring and accelerate drug development.

结核病治疗监测和结果测量:新兴趣和新策略。
尽管出现了新的诊断方法、药物和治疗方案,但结核病仍然是全球公共卫生威胁。结核病控制工作面临的一个重大挑战是监测结核病治疗并确定结核病治疗成功与否。目前对结核病治疗监测的建议依赖于痰液和培养物转化,这些方法敏感性低,周转时间长,存在生物危害风险,而且容易受到污染,削弱了它们作为临床治疗监测工具和药物开发的作用。我们回顾了一系列分子技术和检测方法,这些技术和检测方法可以替代目前基于培养的治疗反应和结果读数,并有可能改变结核病治疗监测和加速药物开发。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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