Synthesis and SAR Evaluation of Mercaptotriazolo derivatives as anti-inflammatory agents.

Abstract

A new series of benzothiazole appended triazole derivatives were synthesized. Characterization is done by FT-IR, Mass, 1 H and 13 C NMR spectroscopic techniques. The newly synthesized compounds were screened for antioxidant and anti inflammatory activities. Experimental data hypothesized compound 7b as highly potent cytotoxicant with lengthened activity. Structure–activity relation interrelates the biological activity and chemical moiety of the molecule. Structurally, 7b is a benzothiazolyltriazole having a pyrrolidine group (five membered ring) attached to two CH2 groups and methyl substituent at 7 th position of the benzothiazole ring.