Clinical outcomes after fresh versus frozen embryo transfer in women with advanced reproductive age undergoing in vitro fertilization: a propensity score-matched cohort study.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI:10.1080/14647273.2023.2189025

Chunyan Sun, Mingming Ye, Yuanyuan Wu, Qiaoyu Chen, Zhenzhen Meng, Lulu Geng, Orhan Bukulmez, Ben W Mol, Xiaoming Teng, Miaoxin Chen

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引用次数: 0

Abstract

This retrospective cohort study aimed to compare clinical outcomes following fresh or frozen embryo transfer (FET) in women with advanced reproductive age (ARA). Women aged 35-45 years who underwent their first autologous fresh or frozen cleavage stage embryo transfer cycle in the Centre for Assisted Reproduction of Shanghai First Maternity and Infant Hospital between January 2016 and December 2020 were included. The primary outcome was live birth after the first embryo transfer of the in vitro fertilization (IVF) cycle. Multiple covariates were used for propensity score matching (PSM) and generalized estimating equations were performed to examine the independent association between FET and live birth. Of the total 1453 patients, 327 patients had FET and 1126 patients had fresh ET. After the PSM procedure, 274 patients were included in each group. The live birth rate was 24.8% in the FET group and 25.2% in the fresh ET group (OR 0.98, 95% CI: 0.67-1.44, P = 0.92). Other pregnancy, perinatal and neonatal outcomes were all comparable between the two groups. This study showed that FET did not improve live birth and other clinical outcomes as compared with fresh embryo transfer in women with ARA who underwent their first IVF cycle.

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高龄育龄女性接受体外受精后新鲜胚胎移植与冷冻胚胎移植的临床结果：倾向得分匹配队列研究。

这项回顾性队列研究旨在比较高龄育龄（ARA）妇女进行新鲜或冷冻胚胎移植（FET）后的临床结果。研究纳入了2016年1月至2020年12月期间在上海市第一妇婴保健院辅助生殖中心接受首次自体新鲜或冷冻卵裂期胚胎移植周期的35-45岁女性。主要结果为体外受精（IVF）周期首次胚胎移植后的活产。使用多个协变量进行倾向得分匹配（PSM），并使用广义估计方程来检验体外受精与活产之间的独立关联。在总共 1453 名患者中，327 名患者进行了 FET，1126 名患者进行了新鲜 ET。经过PSM程序后，每组各有274名患者。FET 组的活产率为 24.8%，新鲜 ET 组为 25.2%（OR 0.98，95% CI：0.67-1.44，P = 0.92）。两组的其他妊娠、围产期和新生儿结局均相当。这项研究表明，与新鲜胚胎移植相比，FET 并不能改善首次接受体外受精周期的 ARA 妇女的活产率和其他临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.