MYC expression and fatty acid oxidation in EGFR-TKI acquired resistance

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2023-11-13 DOI:10.1016/j.drup.2023.101019

GuoSheng Wang , Tao Li , Yuan Wan , Qiang Li

引用次数: 0

Abstract

This report expands on our previous research, highlighting a unique inverse correlation between MYC expression in tumor cells and immune cells during the development of EGFR-TKI resistance. It is observed that MYC expression and fatty acid oxidation (FAO) metabolism in tissue-resident memory (TRM) CD8 + T cells are significantly impaired. These findings offer new insights into the mechanisms of TKI resistance. Although the study is preliminary, it suggests caution when interpreting the effectiveness of MYC inhibitors in reversing TKI resistance, especially when immune factors are not considered.

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EGFR-TKI获得性耐药中MYC表达和脂肪酸氧化

本报告扩展了我们之前的研究，强调了在EGFR-TKI耐药性发展过程中，肿瘤细胞中MYC表达与免疫细胞之间独特的负相关关系。我们观察到，MYC表达和脂肪酸氧化(FAO)代谢在组织常驻记忆(TRM) CD8+ T细胞中显著受损。这些发现为TKI耐药机制提供了新的见解。虽然这项研究是初步的，但它提示在解释MYC抑制剂在逆转TKI耐药方面的有效性时要谨慎，特别是在不考虑免疫因素的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research

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