Association of Human Papillomavirus Infection with Tonsillar Cancers: A Systematic Review.

Q4 Business, Management and Accounting

Revue Francaise de Gestion Pub Date : 2024-02-01 Epub Date: 2023-08-29 DOI:10.1007/s12070-023-04140-2

Sneha Sethi, Alana Shahin, Intisar Nuha Abd Rahim

{"title":"Association of Human Papillomavirus Infection with Tonsillar Cancers: A Systematic Review.","authors":"Sneha Sethi, Alana Shahin, Intisar Nuha Abd Rahim","doi":"10.1007/s12070-023-04140-2","DOIUrl":null,"url":null,"abstract":"Vaccinations have shown a decrease in human papillomavirus (HPV) infection-related cervical cancer in women, but there has been a sharp rise in the HPV infection-related oropharyngeal cancer cases over the past few decades. Recent studies have suggested the association of HPV infections with tonsillar cancers as well and suggestions regarding preventive tonsillectomies in order to achieve a decrease in HPV infection-related oropharyngeal or tonsillar cancer have arisen. However, there is limited cumulative evidence validated at a global level to support the endorsement of this strategy. This research revolves around the concept of burden of tonsillar carcinomas due to oropharyngeal HPV infection. Thus, a systematic review and meta-analysis of existing studies was undertaken to estimate the pooled prevalence of tonsillar cancer associated with oropharyngeal HPV infection. Published articles on tonsillar cancer with and without HPV infection from PubMed, Embase, Scopus and Web of Science were systematically searched from inception until 23 December 2021. A random-effects model was used to estimate the pooled prevalence forest plots. The systematic review revealed that 50% of the reported cases of tonsillar cancer had an oropharyngeal HPV infection, questioning the preventive nature of an early tonsillectomy which is essentially an invasive surgical procedure. Large heterogeneity was reported in the included studies, and there was insufficient data for sub-group analysis. Future research and representative studies are required to thoroughly explore the correlation between HPV infection and tonsillar cancer.Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04140-2.","PeriodicalId":39421,"journal":{"name":"Revue Francaise de Gestion","volume":"1 1","pages":"268-276"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10908725/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue Francaise de Gestion","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12070-023-04140-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Business, Management and Accounting","Score":null,"Total":0}

引用次数: 0

Abstract

Vaccinations have shown a decrease in human papillomavirus (HPV) infection-related cervical cancer in women, but there has been a sharp rise in the HPV infection-related oropharyngeal cancer cases over the past few decades. Recent studies have suggested the association of HPV infections with tonsillar cancers as well and suggestions regarding preventive tonsillectomies in order to achieve a decrease in HPV infection-related oropharyngeal or tonsillar cancer have arisen. However, there is limited cumulative evidence validated at a global level to support the endorsement of this strategy. This research revolves around the concept of burden of tonsillar carcinomas due to oropharyngeal HPV infection. Thus, a systematic review and meta-analysis of existing studies was undertaken to estimate the pooled prevalence of tonsillar cancer associated with oropharyngeal HPV infection. Published articles on tonsillar cancer with and without HPV infection from PubMed, Embase, Scopus and Web of Science were systematically searched from inception until 23 December 2021. A random-effects model was used to estimate the pooled prevalence forest plots. The systematic review revealed that 50% of the reported cases of tonsillar cancer had an oropharyngeal HPV infection, questioning the preventive nature of an early tonsillectomy which is essentially an invasive surgical procedure. Large heterogeneity was reported in the included studies, and there was insufficient data for sub-group analysis. Future research and representative studies are required to thoroughly explore the correlation between HPV infection and tonsillar cancer.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04140-2.

查看原文本刊更多论文

人类乳头瘤病毒感染与扁桃体癌的关系：系统回顾

接种疫苗后，与人类乳头瘤病毒（HPV）感染相关的女性宫颈癌发病率有所下降，但在过去几十年中，与 HPV 感染相关的口咽癌病例却急剧上升。最近的研究表明，HPV 感染与扁桃体癌也有关联，因此有人建议进行预防性扁桃体切除术，以减少与 HPV 感染相关的口咽癌或扁桃体癌。然而，在全球范围内，支持这一策略的累积证据有限。这项研究围绕口咽部 HPV 感染导致的扁桃体癌负担这一概念展开。因此，我们对现有研究进行了系统回顾和荟萃分析，以估算与口咽 HPV 感染相关的扁桃体癌的总体发病率。研究人员系统地检索了从 PubMed、Embase、Scopus 和 Web of Science 上发表的关于扁桃体癌与口咽 HPV 感染相关或不相关的文章，检索时间从开始到 2021 年 12 月 23 日。采用随机效应模型估算了汇集流行率森林图。系统性综述显示，50%的扁桃体癌报告病例有口咽HPV感染，这对早期扁桃体切除术的预防性提出了质疑，因为扁桃体切除术本质上是一种侵入性外科手术。据报道，纳入的研究存在很大的异质性，而且没有足够的数据进行亚组分析。未来的研究和代表性研究需要深入探讨 HPV 感染与扁桃体癌之间的相关性：在线版本包含补充材料，可在 10.1007/s12070-023-04140-2上查阅。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revue Francaise de Gestion Business, Management and Accounting-Business and International Management

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Généraliste et multidisciplinaire, la Revue Française de Gestion est la principale publication francophone de vulgarisation scientifique dans le domaine du management. Son objectif est de permettre aux praticiens et aux chercheurs de communiquer, d’échanger et de soumettre à la critique leurs réflexions et leurs recherches sur l’entreprise et les disciplines de gestion, mais aussi de s’adresser à un large public de gestionnaires désireux de se tenir au courant de l’évolution des sciences et des techniques de gestion.