A Review of Applications and Intracellular Mechanisms of Intense Pulsed Light in Eyelid Inflammatory Diseases.

Photobiomodulation, photomedicine, and laser surgery Pub Date : 2023-03-01 DOI:10.1089/photob.2022.0120

Hongya Zeng, Lan Gong

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引用次数: 2

Abstract

Objective: To evaluate relevant clinical outcomes and conclude possible mechanisms of intense pulsed light (IPL) in eyelid inflammation. Background: IPL devices were primarily applied in cutaneous vascular malformations and have been used in ocular diseases for about 20 years, mostly including meibomian gland dysfunction (MGD), blepharitis, and ocular rosacea. Recent findings: Seventy-two original clinical researches were included, 57 for MGD, 4 for blepharitis or blepharitis-related keratoconjunctivitis, and 11 for rosacea. Dry eye symptoms, (tear) break-up time (BUT), and meibomian structure and/or functions were improved in most patients, but production of reactive oxygen species is an important link in the photobiomodulation mediated by IPL, which can influence numerous signal pathways to achieve anti-inflammatory, anti-infective, and prodifferentiation effects. Conclusions: The evidence suggests that IPL is an effective therapeutic tool for most patients with MGD, but more clinical evidence is needed for other indications.

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强脉冲光在眼睑炎性疾病中的应用及其细胞内机制综述。

目的:评价强脉冲光(IPL)治疗眼睑炎症的相关临床结果，探讨IPL治疗的可能机制。背景:IPL装置主要应用于皮肤血管畸形，在眼部疾病的治疗中已有近20年的历史，主要包括睑板腺功能障碍(MGD)、眼睑炎和眼红斑痤疮。最新发现:纳入72项原始临床研究，57项针对MGD, 4项针对睑缘炎或睑缘相关性角膜结膜炎，11项针对酒渣鼻。大多数患者的干眼症状、(泪液)破裂时间(BUT)和睑板结构和/或功能得到改善，但活性氧的产生是IPL介导的光生物调节的重要环节，它可以影响许多信号通路，从而达到抗炎、抗感染和促分化的作用。结论:有证据表明IPL是大多数MGD患者的有效治疗工具，但其他适应症需要更多的临床证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photobiomodulation, photomedicine, and laser surgery

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