The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis.

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2023-02-01 DOI:10.1089/cell.2022.0091

Haoling Chen, Zijing Huang, Chuxiao Chen

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引用次数: 0

Abstract

Odontogenesis is a complex physiological process that is based on dental tissue-derived mesenchymal stem cells (MSCs). Dental tissue-derived MSCs are the stem cell populations isolated and characterized from different parts of the oral cavity, and are considered as promising candidates for stem cell-based therapy. During odontogenesis, epigenetic factors can influence the proliferation, differentiation, or apoptosis of dental tissue-derived MSCs. As one of the epigenetic modifications, histone acetylation modification is critical for the proper regulation of many biological processes, including transcriptional regulation of cell cycle progression and cell fate. In odontogenesis, histone acetylation and deacetylation play crucial roles in odontogenic differentiation of dental tissue-derived MSCs. In this review, we aim to outline the general features of acetylation modification and describe their roles in odontogenic differentiation of dental tissue-derived MSCs, as well as their future implications in the field of novel regenerative therapies for the dentine-pulp complex.

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组蛋白乙酰化修饰在牙组织源性间充质干细胞和牙形成中的作用。

牙形成是一个复杂的生理过程，以牙组织来源的间充质干细胞(MSCs)为基础。牙组织来源的间充质干细胞是从口腔不同部位分离和鉴定的干细胞群，被认为是干细胞治疗的有希望的候选者。在牙形成过程中，表观遗传因素可以影响牙组织来源的间充质干细胞的增殖、分化或凋亡。组蛋白乙酰化修饰作为一种表观遗传修饰，对细胞周期进程和细胞命运的转录调控等许多生物学过程的正常调控至关重要。在成牙过程中，组蛋白乙酰化和去乙酰化在牙组织源性间充质干细胞的成牙分化中起着至关重要的作用。在这篇综述中，我们旨在概述乙酰化修饰的一般特征，并描述它们在牙组织来源的MSCs的牙源性分化中的作用，以及它们在牙本质-牙髓复合体的新型再生治疗领域的未来意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.