Effect of Thermosensitization with Parthenolide in Thermotherapy of Early Prostate Cancer Combined with Androgen Deprivation ; with an Emphasis on Histopathologic Findings

Abstract

Parthenolide(PTL),a nuclear factor-κB(NF-κB)inhibitor,has been known to have a significant thermo-enhancement efect.The purpose of this study is to report our clinical experiences of using PTL in perioperative period of transurethral microwave thermotherapy(TUMT)for the treatment of early prostate cancer and to compare the results with those of the patients who were treated in the similar manner without PTL administration.Al the patients who underwent TUMT for early prostate cancer were pretreated with androgen deprivation therapy(ADT)at least for 3 months to reduce volume of the prostate to render the TUMT more efective.PTL,daily oral dose of 0.5 mg,was administered during the perioperative period of TUMT. Forty-five patients with early prostate cancer,clinical stage T1c~T2cN0M0 were included in this study.Significant reduction in volume of the prostate(mean 34.6%)was noted after ADT for 3 months. Transurethral resection of the prostate in radical fashion was then performed at least 3 months after TUMT to wait for maturation of histopathologic changes of the prostate glands. Thorough histopathologic study of al the transurethral resection of the prostate(TURP)chips revealed no cancer cel in 41 of 45 patients.Among 4 patients who were found to have remnant cancer cels in TURP chips,1 was with non-viable cancer cels.Whereas,3 were with probably viable cancer Parthenolide in TUMT of prostate cancer・K.Koshiba et al. ― ― 47 Received 3 April,2013,Accepted 14 May,2013.Corresponding author;Tel,+81-3-3821-0502;Fax,+81-3-3821-1194; e-mail,ken604k@ma.kitanet.ne.jp doi:10.3191/thermalmed.29.47 ©2013 Japanese Society for Thermal Medicine cels,but apparently degraded in malignancy.These results were apparently superior to those of the 75 patients who were treated in similar manner before administration of PTL.Analyses were performed using Student’s t-test,chi-square test and Fisher’s exact test and ANOVA.