Susceptibility of urinary Enterobacteriaceae to selected antimicrobials in an out-patient setting in Wallonia-Belgium: retrospective analysis over 5 years period (2018-2022).

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Nadim Azar, Moustapha Khodor, Jacques Choucair, Monzer Hamze, Henri Pirenne
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引用次数: 0

Abstract

Objective: Increasing antimicrobial resistance in urinary tract infection is a major healthcare concern. In this study, we evaluate the patterns of resistance exhibited by the most implicated microorganisms in urine infections. This approach is a prerequisite for an appropriate and successful empiric therapy in ambulatory patients.

Methods: A retrospective study was carried out from January 2018 to September 2022 in Synlab-Collard laboratory, Liège, Belgium; a total of 129,939 Enterobacteriaceae isolated from 120,616 positive urine sample were included.

Results: Sex ratio is 81.6% female and 18.4% male. E. coli is the most common urinary pathogen (70.4% of cases), followed by Klebsiella spp. (13.5%), Proteus spp. (8.5%), and Citrobacter spp. (2.5%). Ampicillin shows the highest resistance at 56%. Nitrofurantoin, the recommended antimicrobial treatment for cystitis in Belgium, expresses an overall resistance rate of 19% in females and 32% in males peaking at 43% in males over 80 years. Fosfomycin and ciprofloxacin display higher resistance rates in subjects over the age of 80 (18%, 24% in females, and 25%, 35% in males respectively). Trimethoprim shows 24% and 29% resistance rate in females and males over the age of 80 respectively.

Conclusion: Even if empiric treatment of suspected UTIs may be of benefit in some cases, it is important for healthcare providers to carefully consider its limitations and evaluate its potential failure rate based on the resistance profiles of urinary Enterobacteriaceae. Susceptibility tests should be performed, and treatments adjusted especially in elderly populations.

比利时瓦隆尼亚门诊尿肠杆菌科对选定抗菌药物的敏感性:5年(2018-2022)回顾性分析。
目的:尿路感染中抗生素耐药性的增加是一个主要的卫生保健问题。在这项研究中,我们评估了尿感染中最相关的微生物所表现出的耐药性模式。这种方法是一个适当的和成功的经验治疗门诊病人的先决条件。方法:回顾性研究于2018年1月至2022年9月在比利时li法兰西市Synlab-Collard实验室进行;从120,616份阳性尿样中分离出129,939株肠杆菌科细菌。结果:性别比为女性81.6%,男性18.4%。大肠杆菌是最常见的泌尿系统病原菌(70.4%),其次是克雷伯氏菌(13.5%)、变形杆菌(8.5%)和柠檬酸杆菌(2.5%)。氨苄西林的耐药性最高,为56%。硝基呋喃妥因是比利时推荐的治疗膀胱炎的抗菌药物,其总体耐药率在女性中为19%,在男性中为32%,在80岁以上的男性中达到43%的峰值。磷霉素和环丙沙星在80岁以上受试者中耐药率较高(女性分别为18%、24%和男性分别为25%、35%)。80岁以上女性和男性对甲氧苄啶的耐药率分别为24%和29%。结论:即使对疑似尿路感染的经验性治疗在某些情况下可能是有益的,但重要的是卫生保健提供者要仔细考虑其局限性,并根据尿肠杆菌科的耐药概况评估其潜在的失败率。应进行药敏试验,并调整治疗方法,特别是对老年人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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