ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of applied biomedicine Pub Date : 2022-12-01 DOI:10.32725/jab.2022.017

Rafael Baltazar Reyes Leon-Cachon, Mauricio Andres Salinas-Santander, Daniela Alejandra Aguilar-Tamez, Paola MarianaValdez-Ortiz, Clara Patricia Rios-Ibarra, Ana Cecilia Cepeda-Nieto, Victor de Jesus Suarez-Valencia, Jesus Antonio Morlett-Chavez

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引用次数: 1

Abstract

Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico.

Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity.

Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

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ADIPOQ-rs2241766多态性与墨西哥青少年胆固醇水平的变化有关。

背景:ADIPOQ基因编码一种脂肪来源的蛋白质激素，在葡萄糖和脂肪酸的体内平衡中起主要作用。然而，先前对ADIPOQ基因变异与代谢紊乱之间的关联研究显示出有争议的结果。在这项研究中，我们评估了ADIPOQ-rs2241766多态性对墨西哥青少年人群多种生化参数(即胰岛素抵抗、动脉粥样硬化指数、超重和肥胖)的影响。方法:采用方便抽样的横断面研究方法，对墨西哥北部356名青少年进行调查。他们按性别和BMI-z评分进行分类。采用常规方法测定血液样本的生化参数。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行基因分型。结果:低体重组和正常体重组GG携带者胆固醇水平显著高于TG和TT携带者(P≤0.05)。然而，ADIPOQ-rs2241766多态性与动脉粥样硬化指数、超重或肥胖之间没有关联。结论:我们的研究结果表明，墨西哥青少年的胆固醇水平受到ADIPOQ-rs2241766多态性的影响，并可能解释ADIPOQ变异如何增加发生代谢疾病的风险。然而，需要进一步的研究来排除其他遗传和非遗传因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied biomedicine PHARMACOLOGY & PHARMACY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.