ENDOTHELIAL STRUCTURE IN RABBITS WITH MODERATE HYPERCHOLESTEROLAEMI

A. Bylock, S. Björkerud, R. Brattsand, G. Hansson, H. Hansson, G. Bondjers
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Abstract

: The aortic surface of rabbits given a supplement of 0.1--0.3 per cent cholesterol to the diet was studied by scanning electron microscopy. In regions where increased haemodynamic strain was anticipated, similar structural changes were observed in normal and hypercholesterolaemic rabbits. However, changes indicating cell injury were more wide-spread in cholesterolfed animals. This suggests that hypercholesterolaemia may increase cell susceptibility to injury. In the same regions, the development of intimal thickenings was observed in cholesterol-fed rabbits. The central parts of such thickenings had been reendothlialized, whereas a region with cell injury surrounded each lesion. In regions with low haemodynamic strain, a loss of fine-structural details was observed in hypercholesterolaemic rabbits. It is suggested that these changes may be related to the deteriorated functional properties of the intact endothelium in such rabbits. In view of these data it is suggested that the interrelationship between hypercholesterolaemia and atherosclerotic arterial disease may partly be due to a deleterious effect of hypercholesterolaemia on the functional and structural integrity of the arterial endothelium.
中度高胆固醇血症家兔的内皮结构
用扫描电子显微镜研究了在饲粮中添加0.1%—0.3%胆固醇的家兔的主动脉表面。在血流动力学应变增加的区域,在正常和高胆固醇血症的兔子中观察到类似的结构变化。然而,表明细胞损伤的变化在胆固醇升高的动物中更为广泛。这表明高胆固醇血症可能增加细胞对损伤的易感性。在相同的区域,胆固醇喂养的家兔观察到内膜增厚的发展。这些增厚的中心部分已经重新内皮化,而每个病变周围都有一个细胞损伤的区域。在血流动力学应变低的区域,高胆固醇血症家兔观察到精细结构细节的丢失。提示这些变化可能与家兔完整内皮功能的恶化有关。鉴于这些数据,提示高胆固醇血症与动脉粥样硬化性疾病之间的相互关系可能部分是由于高胆固醇血症对动脉内皮的功能和结构完整性的有害影响。
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