Precision of Michigan Neuropathy Screening Instrument (MNSI) Tool for the Diagnosis of Diabetic Peripheral Neuropathy Among People with Type 2 Diabetes-A Study from South India.

IF 2.2 4区医学 Q3 DERMATOLOGY

International Journal of Lower Extremity Wounds Pub Date : 2025-12-01 Epub Date: 2023-03-15 DOI:10.1177/15347346231163209

Vijay Viswanathan, Balkhiwala Ahmed Khan, Sukanya Nachimuthu, Satyavani Kumpatla

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引用次数: 0

Abstract

Diabetic peripheral neuropathy (DPN) is one of the risk factors for foot-related complications among people with type 2 diabetes mellitus (T2DM). Hence, we aimed to validate the Michigan Neuropathy Screening Instrument (MNSI) tool against biothesiometer with a cut-off value of ≥25 V and also to determine the cut-off point of MNSI score for the diagnosis of diabetic neuropathy among people with T2DM in India. A cross-sectional study was conducted among 357 people with T2DM in a tertiary care centre for diabetes in Chennai, South India. The eligible study participants underwent testing with a biothesiometer and the MNSI tool was administered. The patient version tool of MNSI was translated to the local language, Tamil. The MNSI scores (1, 1.5, 2, and 2.5) were compared with biothesiometer value. For the MNSI scores of less than 1, 1.5, 2, and 2.5, sensitivities were 97.6%, 97.6%, 96.8%, and 77.8% and specificities were 76.6%, 77.9%, 85.7%, and 88.3% respectively. The cut-off value of MNSI score was derived as two with AUC of 0.934. The sensitivity was 96.8% and the specificity was 85.7% with 89.6% accuracy. The high sensitivity indicates the positive cases are diagnosed correctly. There is no validated tool available for detection of DPN in Indian population. The Indian version of MNSI tool was found to be effective for screening diabetic neuropathy among people with T2DM. The MNSI tool was found to be reliable, convenient, and non-invasive for diagnosis of DPN and can be used in routine clinical settings.

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密歇根神经病变筛查仪（MNSI）工具诊断2型糖尿病周围神经病变的准确性-一项来自南印度的研究

糖尿病周围神经病变（DPN）是2型糖尿病（T2DM）患者足部相关并发症的危险因素之一。因此，我们的目的是验证密歇根神经病变筛查仪器（MNSI）工具与临界值≥25 V的生物测量仪的对比，并确定MNSI评分在印度T2DM患者中诊断糖尿病性神经病变的临界值。一项横断面研究在印度南部金奈的糖尿病三级保健中心对357名2型糖尿病患者进行了研究。符合条件的研究参与者接受了生物测量仪和MNSI工具的测试。MNSI的患者版本工具被翻译成当地语言泰米尔语。将MNSI得分（1,1.5,2和2.5）与生物等距测量值进行比较。对于MNSI评分小于1、1.5、2和2.5的患者，敏感性分别为97.6%、97.6%、96.8%和77.8%，特异性分别为76.6%、77.9%、85.7%和88.3%。MNSI评分的临界值为2，AUC为0.934。灵敏度为96.8%，特异度为85.7%，准确率为89.6%。高灵敏度表明阳性病例诊断正确。没有有效的工具可用于检测DPN在印度人群。印度版本的MNSI工具被发现对筛查T2DM患者的糖尿病神经病变是有效的。MNSI工具可靠、方便、无创诊断DPN，可用于常规临床设置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Lower Extremity Wounds DERMATOLOGY-SURGERY

CiteScore

4.60

自引率

17.60%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).