Broad Antiviral Spectrum of Glycyrrhizic Acid for Human and Veterinary Medicine: Reality or Fiction?

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2023-01-01 Epub Date: 2022-12-01 DOI:10.1159/000528198

Gilberto García-Salazar, Zaida Urbán-Morlán, Susana Mendoza-Elvira, David Quintanar-Guerrero, Sandra Mendoza

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引用次数: 0

Abstract

Background: Emerging virus infections provoke health problems in people and animals, which generate social and economic issues worldwide. This has spurred the search for new pharmacological strategies to confront them.

Summary: The purpose of this review is to draw the reader's attention to pharmacological evaluations of glycyrrhizic acid (GA) and its analogs on the broad range of viruses known in human and veterinary medicine. GA is the main water-soluble constituent extracted from the roots of plants from the genus Glycyrrhiza, commonly known as licorice root. It has long been used due to its broad spectrum of bioactivities, including anti-inflammatory, antiulcer, and antitumor properties. It has also been proposed as an antiviral agent. Medicines derived from GA are currently being used to combat acute and chronic hepatitis and herpes viruses.

Key messages: This review suggests that GA could be a new broad-spectrum antiviral due to its ability to inhibit DNA or RNA viruses both in vitro and in vivo. GA could be a potential drug for preventing and/or treating various viral diseases.

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用于人类和兽医的甘草酸的广泛抗病毒谱：现实还是虚构？

背景：新出现的病毒感染引发了人类和动物的健康问题，造成了全球范围内的社会和经济问题。摘要：本综述旨在提请读者注意甘草酸（GA）及其类似物对人类和兽医已知的多种病毒的药理评估。甘草酸是从甘草属植物（俗称甘草根）的根中提取的主要水溶性成分。由于它具有广泛的生物活性，包括抗炎、抗溃疡和抗肿瘤等特性，长期以来一直被人们使用。它还被认为是一种抗病毒剂。从天麻中提取的药物目前正被用于抗击急慢性肝炎和疱疹病毒：本综述认为，由于天麻具有体外和体内抑制 DNA 或 RNA 病毒的能力，因此可以成为一种新的广谱抗病毒药物。GA可能是预防和/或治疗各种病毒性疾病的潜在药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.