{"title":"Clinical and Translational Implications of an Emerging Developmental Substructure for Autism.","authors":"John N Constantino, Tony Charman, Emily J H Jones","doi":"10.1146/annurev-clinpsy-081219-110503","DOIUrl":null,"url":null,"abstract":"<p><p>A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A growing number of studies in the past five years have indicated that inherited susceptibility may operate through a finite number of early developmental liabilities that, in various permutations and combinations, jointly predict familial recurrence of the convergent syndrome of social communication disability that defines the condition. Here, we synthesize this body of research to derive evidence for a novel developmental substructure for autism, which has profound implications for ongoing discovery efforts to elucidate its neurobiological causes, and to inform future clinical and biomarker studies, early interventions, and personalized approaches to therapy.</p>","PeriodicalId":50755,"journal":{"name":"Annual Review of Clinical Psychology","volume":"17 ","pages":"365-389"},"PeriodicalIF":17.8000,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014692/pdf/nihms-1794187.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Clinical Psychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1146/annurev-clinpsy-081219-110503","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/2/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A growing number of studies in the past five years have indicated that inherited susceptibility may operate through a finite number of early developmental liabilities that, in various permutations and combinations, jointly predict familial recurrence of the convergent syndrome of social communication disability that defines the condition. Here, we synthesize this body of research to derive evidence for a novel developmental substructure for autism, which has profound implications for ongoing discovery efforts to elucidate its neurobiological causes, and to inform future clinical and biomarker studies, early interventions, and personalized approaches to therapy.
期刊介绍：
The Annual Review of Clinical Psychology is a publication that has been available since 2005. It offers comprehensive reviews on significant developments in the field of clinical psychology and psychiatry. The journal covers various aspects including research, theory, and the application of psychological principles to address recognized disorders such as schizophrenia, mood, anxiety, childhood, substance use, cognitive, and personality disorders. Additionally, the articles also touch upon broader issues that cut across the field, such as diagnosis, treatment, social policy, and cross-cultural and legal issues.
Recently, the current volume of this journal has transitioned from a gated access model to an open access format through the Annual Reviews' Subscribe to Open program. All articles published in this volume are now available under a Creative Commons Attribution License (CC BY), allowing for widespread distribution and use. The journal is also abstracted and indexed in various databases including Scopus, Science Citation Index Expanded, MEDLINE, EMBASE, CINAHL, PsycINFO, and Academic Search, among others.
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