The Effect of Perphenazine Add-On Therapy to Matrix Intervention on Control of Craving and Relapse in Methamphetamine Users: A Randomized Controlled Trial

Q4 Medicine

International Journal of High Risk Behaviors and Addiction Pub Date : 2022-06-15 DOI:10.5812/ijhrba-115760

Valli Alla Nasr, M. Salehi, G. Kheirabadi

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引用次数: 0

Abstract

Background: Compulsive behaviors, loss of control, and social and occupational dysfunctions are complications of methamphetamine dependence. Objectives: This study aimed to investigate the effectiveness of perphenazine on control of craving and relapse in methamphetamine users. Methods: This double-blind randomized controlled trial was performed in 2017 - 2018 in Isfahan, Iran. The samples included 40 methamphetamine-dependent subjects referred to drug rehab centers in Isfahan. While the intervention group received perphenazine for eight weeks, the control group received placebo tablets. Also, both groups were followed up for four months. Cocaine Craving Questionnaire-Brief (CCQ-Brief) was filled for each patient before and after the intervention. Results: CCQ-Brief scores were significantly lower in the intervention group compared to the control group (P < 0.0001). The changes in CCQ-Brief scores were also significant among both groups. Conclusions: Adding perphenazine to the matrix program in the treatment of methamphetamine use disorder showed significant effect on the reduction of the craving to methamphetamine.

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母体干预加用奋那嗪治疗对甲基苯丙胺使用者控制渴望和复发的影响:一项随机对照试验

背景:强迫行为、失控、社会和职业功能障碍是甲基苯丙胺依赖的并发症。目的:本研究旨在探讨奋那嗪对甲基苯丙胺服用者的渴望和复吸的控制效果。方法:该双盲随机对照试验于2017 - 2018年在伊朗伊斯法罕进行。样本中包括40名依赖甲基苯丙胺的受试者，他们被送到伊斯法罕的戒毒中心。干预组服用奋那嗪8周，对照组服用安慰剂片。此外，两组都随访了四个月。在干预前后分别填写可卡因渴望问卷(CCQ-Brief)。结果:干预组CCQ-Brief评分明显低于对照组(P < 0.0001)。CCQ-Brief评分在两组间的变化也很显著。结论:在母体方案中加入奋那嗪治疗甲基苯丙胺使用障碍对降低甲基苯丙胺渴望有显著效果。

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来源期刊

International Journal of High Risk Behaviors and Addiction Psychology-Clinical Psychology

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of High Risk Behaviors and Addiction is a clinical journal which is informative to all fields related to the high risk behaviors, addiction, including smoking, alcohol consumption and substance abuse, unsafe sexual behavior, obesity and unhealthy eating habits, physical inactivity, and violence, suicidal behavior, and self-injurious behaviors. International Journal of High Risk Behaviors and Addiction is an authentic clinical journal which its content is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates, and consensus statements of the clinical relevance of Risky behaviors and addiction. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in this journal.