Synthesis and in vitro anticancer evaluation of 2-isopropyl-5-methylphenol Loaded PLGA based iron oxide nanoparticles

Biomedicine & Preventive Nutrition Pub Date : 2014-04-01 DOI:10.1016/j.bionut.2013.12.004

Balan Rajan , Shanmugam Sathish , Subramaniyan Jayakumar , Arumugam Madankumar , Krishnan Gokuladhas , Thandavamoorthy Premkumar , Ramasamy Elamaran , Mani Gopikrishnan , Thiruvengadam Devaki

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引用次数: 9

Abstract

For precise delivery of 2-isopropyl-5-methylphenol (IPMP), Poly (lactic-co-glycolic acid) (PLGA) based superparamagnetic nanoparticles loaded with IPMP (IMNPs) were synthesized and characterized. IMNPs with a particle size of 223 ± 20.7 nm were synthesized by solvent evaporation method. Fe₃O₄ nanoparticles of 33 ± 3.63 nm encapsulated in the PLGA polymer provides the superparamagnetic property to the IMNPs. The entrapment efficacy of Fe₃O₄ nanoparticles, 2-isopropyl-5-methylphenol and average cumulative percentage release profile of IPMP from the IMNPs were investigated. The magnetic nanocarrier enhanced the stability and activity of IPMP. Release of IPMP from IMNPs occurred in a controlled manner. The cytotoxicity of IMNPs against human hepatoma Hep3B cell line was investigated and the IC₅₀ value was found to be 20 μg/mL for IMNPs compared to 25 μg/mL for free IPMP. The result showed that IMNPs had significant antitumor activity. Therefore, IMNPs may be considered as an effective anticancer drug delivery system for cancer chemotherapy.

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2-异丙基-5-甲基苯酚负载PLGA基氧化铁纳米颗粒的合成及体外抗癌评价

为了精确递送2-异丙基-5-甲基苯酚(IPMP)，合成了以聚乳酸-羟基乙酸(PLGA)为基负载IPMP的超顺磁纳米粒子(IMNPs)并对其进行了表征。采用溶剂蒸发法制备了粒径为223±20.7 nm的纳米颗粒。包裹在PLGA聚合物中的Fe3O4纳米颗粒(33±3.63 nm)为imnp提供了超顺磁性。研究了Fe3O4纳米颗粒、2-异丙基-5-甲基苯酚的包封效果以及IPMP从IMNPs中平均累积百分比释放曲线。磁性纳米载体增强了IPMP的稳定性和活性。从imnp中释放IPMP是在受控的方式下进行的。研究了IMNPs对人肝癌Hep3B细胞株的细胞毒性，发现IMNPs的IC50值为20 μg/mL，而游离IPMP的IC50值为25 μg/mL。结果表明，IMNPs具有明显的抗肿瘤活性。因此，IMNPs可能被认为是一种有效的抗癌药物递送系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedicine & Preventive Nutrition

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