In Utero Exposure to Maternal Electronic Nicotine Delivery System use Demonstrate Alterations to Craniofacial Development.

IF 1.2 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Cleft Palate-Craniofacial Journal Pub Date : 2024-08-01 Epub Date: 2023-03-14 DOI:10.1177/10556656231163400
Rajiv Kishinchand, Mark Boyce, Heema Vyas, Leslie Sewell, Amr Mohi, Lexie Brengartner, Roy Miller, Matthew W Gorr, Loren E Wold, James Cray
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引用次数: 0

Abstract

Objective: Develop a model for the study of Electronic Nicotine Device (ENDS) exposure on craniofacial development.

Design: Experimental preclinical design followed as pregnant murine dams were randomized and exposed to filtered air exposure, carrier exposure consisting of 50% volume of propylene glycol and vegetable glycine (ENDS Carrier) respectively, or carrier exposure with 20 mg/ml of nicotine added to the liquid vaporizer (ENDS carrier with nicotine).

Setting: Preclinical murine model exposure using the SciReq exposure system.

Participants: C57BL6 adult 8 week old female pregnant mice and exposed in utero litters.

Interventions: Exposure to control filtered air, ENDS carrier or ENDS carrier with nicotine added throughout gestation at 1 puff/minute, 4 h/day, five days a week.

Main outcome measures: Cephalometric measures of post-natal day 15 pups born as exposed litters.

Results: Data suggests alterations to several facial morphology parameters in the developing offspring, suggesting electronic nicotine device systems may alter facial growth if used during pregnancy.

Conclusions: Future research should concentrate on varied formulations and exposure regimens of ENDS to determine timing windows of exposures and ENDS formulations that may be harmful to craniofacial development.

子宫内暴露于母体电子尼古丁输送系统显示出颅面发育的改变。
目标:为研究电子尼古丁装置(ENDS)暴露对颅面发育的影响建立模型:开发一种模型,用于研究电子尼古丁装置(ENDS)暴露对颅面发育的影响:设计:采用临床前实验设计,将怀孕的小鼠随机分配并暴露于过滤空气暴露、分别由50%体积的丙二醇和植物甘氨酸组成的载体暴露(ENDS载体)或在液体蒸发器中添加20毫克/毫升尼古丁的载体暴露(含尼古丁的ENDS载体):使用 SciReq 暴露系统进行临床前小鼠模型暴露:干预措施:干预措施:在整个妊娠期暴露于对照组过滤空气、ENDS载体或添加尼古丁的ENDS载体,1次/分钟,4小时/天,每周5天:主要结果测量:对接触尼古丁的幼鼠出生后第 15 天进行头颅测量:结果:数据表明,发育中的后代面部形态参数会发生变化,这表明如果在孕期使用电子尼古丁装置系统,可能会改变面部发育:未来的研究应集中于ENDS的不同配方和暴露方案,以确定可能对颅面发育有害的暴露时间窗口和ENDS配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
36.40%
发文量
215
期刊介绍: The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.
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