Using genetic algorithm combining adaptive neuro-fuzzy inference system and fuzzy differential equation to optimizing gene

Abstract

Once a recombinant DNA is inserted into bacteria, these bacteria will make protein based on this recombinant DNA. This protein is known as “Recombinant protein”. The demand of recombinant proteins has increased as more applications in several fields become a commercial reality [1]. For instance, today, more than 75 recombinant proteins are utilized as pharmaceuticals, and more than 360 new medicines based on recombinant proteins are under development (www.phrma.org).