Correlation between the regional brain volume and glymphatic system activity in progressive supranuclear palsy.

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2023-03-13 DOI:10.1159/000530075

Miho Ota, Noriko Sato, Yuji Takahashi, Yoko Shigemoto, Yukio Kimura, Moto Nakaya, Emiko Chiba, Hiroshi Matsuda

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引用次数: 1

Abstract

Introduction: Tau protein accumulation in the brain is thought to be one of the causes of progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as a waste drainage system in the brain that promotes the elimination of amyloid-beta and tau protein. We here evaluated the relationships between glymphatic system activity and regional brain volumes in PSP patients.

Method: Subjects were 24 patients with PSP and 42 healthy participants who underwent diffusion tensor imaging (DTI). We computed the diffusion tensor image analysis along the perivascular space (DTI‑ALPS) index as a proxy of glymphatic system activity, and estimated the relationships between the DTI‑ALPS index and regional brain volume in PSP patients by whole-brain and region-of-interest analyses, including analyses of the midbrain and third and lateral ventricles.

Results: The DTI‑ALPS index was significantly lower in patients with PSP, compared with healthy subjects. Further, there were significant correlations between the DTI‑ALPS index and the regional brain volumes in the midbrain tegmentum, pons, right frontal lobe, and lateral ventricles in patients with PSP.

Conclusions: Our data suggest that the DTI‑ALPS index is a good biomarker for PSP and might be effective to distinguish PSP from other neurocognitive disorders.

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进行性核上性麻痹局部脑容量与淋巴系统活动的相关性。

Tau蛋白在大脑中的积累被认为是进行性核上性麻痹(PSP)的原因之一。十年前，人们发现了类淋巴系统，它是大脑中的一个废物排泄系统，可以促进淀粉样蛋白和tau蛋白的消除。我们在此评估了PSP患者的淋巴系统活动和区域脑容量之间的关系。方法:选取24例PSP患者和42例健康人进行弥散张量成像(DTI)检查。我们计算了沿血管周围空间的弥散张量图像分析(DTI - ALPS)指数作为淋巴系统活性的代理，并通过全脑和兴趣区分析(包括中脑、第三脑室和侧脑室的分析)估计了PSP患者DTI - ALPS指数与区域脑容量之间的关系。结果:与健康受试者相比，PSP患者的DTI - ALPS指数明显降低。此外，PSP患者的DTI - ALPS指数与中脑被盖、脑桥、右额叶和侧脑室的区域脑容量存在显著相关性。结论:我们的数据表明，DTI - ALPS指数是一个很好的PSP生物标志物，可以有效地将PSP与其他神经认知障碍区分开来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.