Lower Omega-3 Status Associated with Higher Erythrocyte Distribution Width and Neutrophil-Lymphocyte Ratio in UK Biobank Cohort

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2022-12-13 DOI:10.1101/2022.12.09.22283290

M. McBurney, N. Tintle, William S. Harris

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引用次数: 0

Abstract

Abstract High red blood distribution width (RDW) is associated with decreased red blood cell deformability, and high neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation and innate-adaptive immune system imbalance. Both RDW and NLR are predictors of chronic disease risk and mortality. Omega-3 index (O3I) values have previously been shown to be inversely associated with RDW and NLR levels. Our objective was to determine if total plasma long chain omega-3 fatty acids (Omega3%) measured in the UK Biobank cohort were associated with RDW and NLR values. RDW- and NLR- relationships with Omega3% were characterized in 109,191 adults (58.4% female). RDW- and NLR-Omega3% relationships were inversely associated with Omega3% (both p<0.0001). These cross-sectional associations confirm previous findings that increasing RDW and NLR values are associated with low O3I. The hypothesis that RDW and/or NLR values can be reduced in individuals with less-than optimal long chain omega 3 values need to be tested in randomized controlled intervention trials using EPA and/or DHA.

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在英国生物银行队列中，较低的Omega-3水平与较高的红细胞分布宽度和中性粒细胞-淋巴细胞比率相关

高红血球分布宽度(RDW)与红细胞变形能力降低有关，而高中性粒细胞-淋巴细胞比率(NLR)是全身性炎症和先天适应性免疫系统失衡的生物标志物。RDW和NLR都是慢性疾病风险和死亡率的预测因子。Omega-3指数(O3I)值先前已被证明与RDW和NLR水平呈负相关。我们的目的是确定在UK Biobank队列中测量的血浆总长链omega-3脂肪酸(Omega3%)是否与RDW和NLR值相关。在109,191名成年人(58.4%为女性)中发现了RDW-和NLR-与omega - 3%的关系。RDW-和nlr - ω - 3%关系与ω - 3%呈负相关(均p<0.0001)。这些横断面关联证实了先前的研究结果，即RDW和NLR值的增加与低O3I相关。对于低于最佳长链omega - 3值的个体，RDW和/或NLR值可以降低的假设需要在使用EPA和/或DHA的随机对照干预试验中进行验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.